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Medicines 2015, 2(3), 220-235; doi:10.3390/medicines2030220

Potent and Synergistic Extract Combinations from Terminalia Catappa, Terminalia Mantaly and Monodora tenuifolia Against Pathogenic Yeasts

1
Antimicrobial Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Messa-Yaoundé, Cameroon
2
Clinical Biology Laboratory, Yaoundé Central Hospital, P.O. Box 87, Messa-Yaoundé, Cameroon
3
IRD UMI 233 TransVIHMI—UM INSERM U1175 TransVIHMI Laboratoire de Parasitologie et Mycologie Médicale, UFR Pharmacie, Université de Montpellier 1, 15, Avenue Charles Flahault—BP 14491 34093 Montpellier, France
4
Laboratory of Natural Products and Organic Synthesis, Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Messa-Yaoundé, Cameroon
*
Author to whom correspondence should be addressed.
Academic Editor: Ronan Batista
Received: 18 June 2015 / Revised: 11 August 2015 / Accepted: 17 August 2015 / Published: 26 August 2015
(This article belongs to the Special Issue Medicinal Plants and Phytomedicines)
View Full-Text   |   Download PDF [294 KB, uploaded 26 August 2015]   |  

Abstract

Mycoses caused by Candida and Cryptococcus species, associated with the advent of antifungal drug resistance have emerged as major health problems. Improved control measures and innovative therapies are needed. This paper describes results from the screening of bio-guided fractionated extracts alone and combinations of Terminalia catappa, Terminalia mantaly and Monodora tenuifolia harvested in Cameroon. Crude ethanolic, hydro-ethanolic and aqueous extracts and bio-guided fractions were screened for antifungal activity against isolates of C. albicans, C. glabrata, C. parapsilosis and Cr. neoformans and the reference strain C. albicans NR-29450. Minimal inhibitory concentrations (MIC) were determined using a broth micro dilution method according to the Clinical & Laboratory Standards Institute (CLSI). Time kill kinetics of extracts alone and in combination were also evaluated. Extracts from T. mantaly stem bark were the most active with the best MIC values ranging from 0.04 mg/mL to 0.16 mg/mL. Synergistic interactions were observed with combinations of sub-fractions from M. tenuifolia, T. mantaly and T. catappa. Combination of sub-fractions from M. tenuifolia and T. mantaly (C36/C12) showed synergistic interaction and fungicidal effect against four out of five tested yeasts. These results support further investigation of medicinal plant extracts alone and in combination as starting points for the development of alternative antifungal therapy. View Full-Text
Keywords: Terminalia catappa; Terminalia mantaly; Monodora tenuifolia; antifungal activity; bio-guided fractionation; combinations Terminalia catappa; Terminalia mantaly; Monodora tenuifolia; antifungal activity; bio-guided fractionation; combinations
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ngouana, T.K.; Mbouna, C.D.J.; Kuipou, R.M.T.; Tchuenmogne, M.A.T.; Zeuko’o, E.M.; Ngouana, V.; Mallié, M.; Bertout, S.; Boyom, F.F. Potent and Synergistic Extract Combinations from Terminalia Catappa, Terminalia Mantaly and Monodora tenuifolia Against Pathogenic Yeasts. Medicines 2015, 2, 220-235.

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