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Medicines 2015, 2(3), 186-211; doi:10.3390/medicines2030186

Inhibiting Microbial Toxins Using Plant-Derived Compounds and Plant Extracts

Department of Animal Science, University of Connecticut, Storrs, CT 06269, USA
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Author to whom correspondence should be addressed.
Academic Editor: Ronan Batista
Received: 3 July 2015 / Revised: 22 July 2015 / Accepted: 23 July 2015 / Published: 31 July 2015
(This article belongs to the Special Issue Medicinal Plants and Phytomedicines)
View Full-Text   |   Download PDF [291 KB, uploaded 31 July 2015]

Abstract

Many pathogenic bacteria and fungi produce potentially lethal toxins that cause cytotoxicity or impaired cellular function either at the site of colonization or other locations in the body through receptor-mediated interactions. Various factors, including biotic and abiotic environments, competing microbes, and chemical cues affect toxin expression in these pathogens. Recent work suggests that several natural compounds can modulate toxin production in pathogenic microbes. However, studies explaining the mechanistic basis for their effect are scanty. This review discusses the potential of various plant-derived compounds for reducing toxin production in foodborne and other microbes. In addition, studies highlighting their anti-toxigenic mechanism(s) are discussed. View Full-Text
Keywords: plant-derived compounds; plant extracts; bacterial toxins; mycotoxins; toxin inhibition; anti-virulence strategies plant-derived compounds; plant extracts; bacterial toxins; mycotoxins; toxin inhibition; anti-virulence strategies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Upadhyay, A.; Mooyottu, S.; Yin, H.; Nair, M.S.; Bhattaram, V.; Venkitanarayanan, K. Inhibiting Microbial Toxins Using Plant-Derived Compounds and Plant Extracts. Medicines 2015, 2, 186-211.

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