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Medicines, Volume 11, Issue 3

2024 March - 2 articles

Cover Story: Pharmacogenomics (PGx) can facilitate the transition to patient-specific drug regimens and thus improve their efficacy and reduce toxicity. The aim of this study was to evaluate the overlap of PGx classification for drug absorption, distribution, metabolism, and elimination (ADME)-related genes in the U.S. Food and Drug Administration (FDA) PGx labeling and in the Clinical Pharmacogenetics Implementation Consortium (CPIC) database. FDA-approved drugs and PGx labeling for ADME genes were identified in the CPIC database. Drugs were filtered by their association with ADME (pharmacokinetics)-related genes, PGx FDA labeling class, and CPIC evidence level. FDA PGx labeling was classified as either actionable, informative, testing recommended, or testing required, and varying CPIC evidence levels as either A, B, C, or D. View this paper

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Article

1 Citations

3,349 Views

11 Pages

Triple Silencing of HSP27, cFLIP, and CLU Genes Promotes the Sensitivity of Doxazosin-Induced Apoptosis in PC-3 Prostate Cancer Cells

Jeong Man Cho,
Sojung Sun,
Eunji Im,
Hyunwon Yang and
Tag Keun Yoo

Medicines2024, 11(3), 7;https://doi.org/10.3390/medicines11030007

21 February 2024

Background: This study investigated how the expression of heat shock protein 27 (HSP27), cellular FLICE-like inhibitory protein (cFLIP), and clusterin (CLU) affects the progression of cancer cells and their susceptibility to doxazosin-induced apoptos...

(This article belongs to the Section Cancer Biology and Anticancer Therapeutics)

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5 Citations

6,049 Views

16 Pages

ADME Gene-Related Pharmacogenomic Labeling of FDA-Approved Drugs: Comparison with Clinical Pharmacogenetics Implementation Consortium (CPIC) Evidence Levels

Subrata Deb,
Robert Hopefl,
Anthony Allen Reeves and
Dena Cvetkovic

Medicines2024, 11(3), 6;https://doi.org/10.3390/medicines11030006

20 February 2024

Pharmacogenomics (PGx) can facilitate the transition to patient-specific drug regimens and thus improve their efficacy and reduce toxicity. The aim of this study was to evaluate the overlap of PGx classification for drug absorption, distribution, met...

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Medicines - ISSN 2305-6320

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