Next Article in Journal
The In Vitro Impact of the Herbicide Roundup on Human Sperm Motility and Sperm Mitochondria
Previous Article in Journal
Zinc Ameliorate Oxidative Stress and Hormonal Disturbance Induced by Methomyl, Abamectin, and Their Mixture in Male Rats
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessReview
Toxics 2017, 5(4), 38; doi:10.3390/toxics5040038

Antioxidants Protect against Arsenic Induced Mitochondrial Cardio-Toxicity

1
Department of Environmental Science and Health, University of Nevada, Reno, NV 89557, USA
2
Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA
3
School of Community Health Sciences, University of Nevada, Reno, NV 89557, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Judit Smits, Rubhana Raqib and Wayne Briner
Received: 30 September 2017 / Revised: 29 November 2017 / Accepted: 1 December 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Arsenic Toxicity)
View Full-Text   |   Download PDF [1210 KB, uploaded 5 December 2017]   |  

Abstract

Arsenic is a potent cardiovascular toxicant associated with numerous biomarkers of cardiovascular diseases in exposed human populations. Arsenic is also a carcinogen, yet arsenic trioxide is used as a therapeutic agent in the treatment of acute promyelotic leukemia (APL). The therapeutic use of arsenic is limited due to its severe cardiovascular side effects. Many of the toxic effects of arsenic are mediated by mitochondrial dysfunction and related to arsenic’s effect on oxidative stress. Therefore, we investigated the effectiveness of antioxidants against arsenic induced cardiovascular dysfunction. A growing body of evidence suggests that antioxidant phytonutrients may ameliorate the toxic effects of arsenic on mitochondria by scavenging free radicals. This review identifies 21 antioxidants that can effectively reverse mitochondrial dysfunction and oxidative stress in cardiovascular cells and tissues. In addition, we propose that antioxidants have the potential to improve the cardiovascular health of millions of people chronically exposed to elevated arsenic concentrations through contaminated water supplies or used to treat certain types of leukemias. Importantly, we identify conceptual gaps in research and development of new mito-protective antioxidants and suggest avenues for future research to improve bioavailability of antioxidants and distribution to target tissues in order reduce arsenic-induced cardiovascular toxicity in a real-world context. View Full-Text
Keywords: arsenic toxicity; cardiovascular; antioxidant; superoxide; oxidative stress arsenic toxicity; cardiovascular; antioxidant; superoxide; oxidative stress
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Pace, C.; Dagda, R.; Angermann, J. Antioxidants Protect against Arsenic Induced Mitochondrial Cardio-Toxicity. Toxics 2017, 5, 38.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxics EISSN 2305-6304 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top