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Toxics 2014, 2(2), 226-246; doi:10.3390/toxics2020226

Overview of the Current State-of-the-Art for Bioaccumulation Models in Marine Mammals

1
Systemic Physiological and Ecotoxicological Research (SPHERE), Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
2
Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
3
Environmental and Resource Studies Program and Environmental and Life Sciences Graduate Program, Trent University, Peterborough, ON K9J7B8, Canada
Present Address: National Research Center for Environmental Toxicology (Entox), The University of Queensland, 39 Kessels Road, Coopers Plains, QLD 4108, Australia
*
Author to whom correspondence should be addressed.
Received: 16 April 2014 / Revised: 19 May 2014 / Accepted: 20 May 2014 / Published: 27 May 2014
(This article belongs to the Special Issue Risk Assessment of Environmental Contaminants)
View Full-Text   |   Download PDF [486 KB, uploaded 27 May 2014]   |  

Abstract

Information regarding the (toxico)kinetics of a chemical in organisms can be integrated in mathematical equations thereby creating bioaccumulation models. Such models can reconstruct previous exposure scenarios, provide a framework for current exposures and predict future situations. As such, they are gaining in popularity for risk assessment purposes. Since marine mammals are protected, the modeling process is different and more difficult to complete than for typical model organisms, such as rodents. This review will therefore discuss the currently available models for marine mammals, address statistical issues and knowledge gaps, highlight future perspectives and provide general do’s and don’ts. View Full-Text
Keywords: PBPK models; marine mammals; exposure; bioaccumulation; organic pollutants PBPK models; marine mammals; exposure; bioaccumulation; organic pollutants
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Weijs, L.; Hickie, B.E.; Blust, R.; Covaci, A. Overview of the Current State-of-the-Art for Bioaccumulation Models in Marine Mammals. Toxics 2014, 2, 226-246.

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