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Foods 2016, 5(4), 83; doi:10.3390/foods5040083

Stimulatory Effects of Cinnamon Extract (Cinnamomum cassia) during the Initiation Stage of 3T3-L1 Adipocyte Differentiation

Food and Nutritional Sciences, Department of Family and Consumer Sciences, North Carolina Agricultural and Technical State University, 1601 E. Market Street, Greensboro, NC 27411, USA
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Antonello Santini
Received: 13 October 2016 / Revised: 21 November 2016 / Accepted: 29 November 2016 / Published: 6 December 2016
(This article belongs to the Special Issue Nutraceuticals: The New Frontier)
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Abstract

Cinnamon (Cinnamomum cassia) has an anti-diabetic effect by possibly increasing the lipid storage capacity of white adipocytes; however, this effect remains controversial. The aim of this study was to examine which stage of adipogenesis is critical for the stimulatory effect of cinnamon in adipogenesis using 3T3-L1 cells. Cells were treated with cinnamon extract during three different stages of adipogenesis. We found that genes related to adipogenesis and lipogenesis were enhanced when cinnamon extract was administered during the initiation stage of differentiation but not when administered during the preadipocyte and post stages of differentiation. At the same time, genes that were involved in the regulation of fatty acid oxidation were unexpectedly upregulated. Taken together, cinnamon may boost lipid storage in white adipocytes and increase the fatty acid oxidation capacity throughout the initiation stage of differentiation, which may be beneficial for the prevention of obesity-induced type II diabetes. View Full-Text
Keywords: cinnamon; white adipocyte differentiation; fatty acid oxidation; lipogenesis; adipogenesis cinnamon; white adipocyte differentiation; fatty acid oxidation; lipogenesis; adipogenesis
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Lee, S.G.; Siaw, J.A.; Kang, H.W. Stimulatory Effects of Cinnamon Extract (Cinnamomum cassia) during the Initiation Stage of 3T3-L1 Adipocyte Differentiation. Foods 2016, 5, 83.

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