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Foods 2016, 5(4), 84; doi:10.3390/foods5040084

How Can Diet Affect the Accumulation of Advanced Glycation End-Products in the Human Body?

1
University Lille, Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, F-59000 Lille, France
2
UniLaSalle, EGEAL Unit, F-60026 Beauvais, France
*
Author to whom correspondence should be addressed.
Academic Editor: Cristina Delgado-Andrade
Received: 8 November 2016 / Revised: 29 November 2016 / Accepted: 30 November 2016 / Published: 6 December 2016
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Abstract

The accumulation of advanced glycation end products (AGEs) is associated with the complications of diabetes, kidney disease, metabolic disorders and degenerative diseases. It is recognized that the pool of glycation products found in the human body comes not only from an endogenous formation, but also from a dietary exposure to exogenous AGEs. In recent years, the development of pharmacologically-active ingredients aimed at inhibiting endogenous glycation has not been successful. Since the accumulation of AGEs in the human body appears to be progressive throughout life, an early preventive action against glycation could be effective through dietary adjustments or supplementation with purified micronutrients. The present article provides an overview of current dietary strategies tested either in vitro, in vivo or both to reduce the endogenous formation of AGEs and to limit exposure to food AGEs. View Full-Text
Keywords: glycation; Maillard; advanced glycation end products; carboxymethyllysine; calorie restriction; fructose; probiotics; vitamins; diabetes; ageing glycation; Maillard; advanced glycation end products; carboxymethyllysine; calorie restriction; fructose; probiotics; vitamins; diabetes; ageing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guilbaud, A.; Niquet-Leridon, C.; Boulanger, E.; Tessier, F.J. How Can Diet Affect the Accumulation of Advanced Glycation End-Products in the Human Body? Foods 2016, 5, 84.

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