Next Article in Journal
Quantitative Analysis of Velopharyngeal Movement by Applying Principal Component Analysis to Range Images Produced by a Three-Dimensional Endoscope
Previous Article in Journal
Human Gingival Crevicular Fluids (GCF) Proteomics: An Overview
Previous Article in Special Issue
Angiogenesis in the Development of Medication-Related Osteonecrosis of the Jaws: An Overview
Article Menu

Export Article

Open AccessCase Report
Dent. J. 2017, 5(1), 13; doi:10.3390/dj5010013

Osteonecrosis of the Jaw (ONJ) in Osteoporosis Patients: Report of Delayed Diagnosis of a Multisite Case and Commentary about Risks Coming from a Restricted ONJ Definition

1
Dental Clinic, Health Sciences Department, University of Eastern Piedmont “A. Avogadro”, 28100, Novara, Italy
2
Oral Medicine and Laser Surgery Unit, University Center of Dentistry, Department of Medicine and Surgery, University of Parma, 43121, Parma, Italy
3
Centro di Documentazione Osteonecrosi dei Mascellari, 15121,Alessandria, Italy
4
Radiology Unit, Alessandria Hospital, 15121, Alessandria, Italy
5
Innovative Research Laboratory for Wound Healing, Health Sciences Department, University of Eastern Piedmont “A. Avogadro”, 28100, Novara, Italy
6
Oncology Unit, Alessandria Hospital, 15121, Alessandria, Italy
*
Author to whom correspondence should be addressed.
Received: 20 January 2017 / Revised: 3 March 2017 / Accepted: 10 March 2017 / Published: 16 March 2017
(This article belongs to the Special Issue New Cancer and Osteoporosis Therapies and Osteocrosis of the Jaws)
View Full-Text   |   Download PDF [4529 KB, uploaded 17 March 2017]   |  

Abstract

Osteonecrosis of the jaws (ONJ) in osteoporosis patients has been defined as rare, but the number of reported cases is increasing. We report a case of delayed ONJ diagnosis in a patient, who was being treated with alendronate, developing bone alterations both in maxilla and in mandible. Underestimation of ONJ incidence and missed or delayed ONJ diagnosis in osteoporosis patients might derive from lack of awareness of health providers as well as from an ONJ definition that is too restricted. The more recent definition of medication-related osteonecrosis of the jaws (MRONJ) released in 2014 by the American Association of Oral Maxillofacial Surgeons (AAOMS) accept fistula, besides bone exposure, as a major sign of disease, but it seems to be insufficient since it excludes all cases of ONJ disease without bone exposure. A new MRONJ definition is needed to avoid missing or delayed diagnosis. View Full-Text
Keywords: bisphosphonate; alendronate; osteoporosis; osteonecrosis of jaw; BRONJ; MRONJ; laser therapy bisphosphonate; alendronate; osteoporosis; osteonecrosis of jaw; BRONJ; MRONJ; laser therapy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Migliario, M.; Mergoni, G.; Vescovi, P.; Martino, I.D.; Alessio, M.; Benzi, L.; Renò, F.; Fusco, V. Osteonecrosis of the Jaw (ONJ) in Osteoporosis Patients: Report of Delayed Diagnosis of a Multisite Case and Commentary about Risks Coming from a Restricted ONJ Definition. Dent. J. 2017, 5, 13.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Dent. J. EISSN 2304-6767 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top