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Dent. J. 2017, 5(1), 12; doi:10.3390/dj5010012

Human Gingival Crevicular Fluids (GCF) Proteomics: An Overview

1
Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia
2
Department of Orthodontics, Fatima Jinnah Dental College, Karachi 78650, Pakistan
3
Preventive Dental Sciences, College of Dentistry, Dar-Al-Uloom University, Riyadh 13314, Saudi Arabia
4
Department of Dentistry, Riyadh Consultative Clinics, Riyadh 11313, Saudi Arabia
5
Department of Restorative Dentistry, College of Dentistry, Al-Taibah University, Medina Munawwarah 41311, Saudi Arabia
6
Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad 44000, Pakistan
*
Author to whom correspondence should be addressed.
Academic Editor: Jukka Meurman
Received: 21 January 2017 / Accepted: 18 February 2017 / Published: 22 February 2017
View Full-Text   |   Download PDF [2118 KB, uploaded 23 February 2017]   |  

Abstract

Like other fluids of the human body, a gingival crevicular fluid (GCF) contains proteins, a diverse population of cells, desquamated epithelial cells, and bacteria from adjacent plaque. Proteomic tools have revolutionized the characterization of proteins and peptides and the detection of early disease changes in the human body. Gingival crevicular fluids (GCFs) are a very specific oral cavity fluid that represents periodontal health. Due to their non-invasive sampling, they have attracted proteome research and are used as diagnostic fluids for periodontal diseases and drug analysis. The aim of this review is to explore the proteomic science of gingival crevicular fluids (GCFs), their physiology, and their role in disease detection. View Full-Text
Keywords: proteomics; proteins; biomarkers; gingival crevicular fluids (GCFs); dentistry proteomics; proteins; biomarkers; gingival crevicular fluids (GCFs); dentistry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Khurshid, Z.; Mali, M.; Naseem, M.; Najeeb, S.; Zafar, M.S. Human Gingival Crevicular Fluids (GCF) Proteomics: An Overview. Dent. J. 2017, 5, 12.

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