Next Article in Journal / Special Issue
Angiogenesis in the Development of Medication-Related Osteonecrosis of the Jaws: An Overview
Previous Article in Journal
Quality of Life and Poor Oral Health: A Comparison of Postmenopausal Women
Previous Article in Special Issue
Role of Teriparatide in Medication-Related Osteonecrosis of the Jaws (MRONJ)
Article Menu

Export Article

Open AccessArticle
Dent. J. 2016, 4(4), 45; doi:10.3390/dj4040045

Osteonecrosis of the Jaws (ONJ) after Bisphosphonate Treatment in Patients with Multiple Myeloma: Decreasing ONJ Incidence after Adoption of Preventive Measures

1
Haematology Unit, Alessandria Hospital, 15121 Alessandria AL, Italy
2
Oncology Unit, Alessandria Hospital, 15121 Alessandria AL, Italy
3
Centro Documentazione Osteonecrosi, Alessandria Hospital, 15121 Alessandria AL, Italy
4
Maxillofacial Unit, Alessandria Hospital, 15121 Alessandria AL, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Christian Walter
Received: 31 August 2016 / Revised: 6 November 2016 / Accepted: 14 November 2016 / Published: 1 December 2016
(This article belongs to the Special Issue New Cancer and Osteoporosis Therapies and Osteocrosis of the Jaws)
View Full-Text   |   Download PDF [224 KB, uploaded 1 December 2016]

Abstract

Bisphosphonates (BPs) are administered to Multiple Myeloma (MM) patients with bone lytic lesion. Osteonecrosis of the Jaw (ONJ) is a complication reported since 2003 in patients treated with intravenous (IV) BPs such as zoledronic acid and pamidronate, with 6%–26.3% frequency in early literature series, before some preventive measures were recommended. We evaluated the occurrence of ONJ with and without dental preventive measures in MM patients treated with BPs in our centre between 1996 and 2015. Since 2005, MM patients (already under treatment or before treatment) underwent a baseline mouth assessment (dental visit, Rx orthopantomography, and eventual tooth avulsion or dental care if necessary) and were followed by a multidisciplinary team. We reviewed the charts of 119 MM patients receiving IV BPs, classified into 3 groups: (a) “historic group” (21 patients who had started BP treatment in years before the awareness of ONJ); (b) “screening group” (20 patients starting BPs without baseline evaluation); and (c) “prevention group” (78 patients starting therapy only after baseline preventive assessment and eventual dental care measures). ONJ was observed in 3/21 patients (14.2%) from group a, in 2/20 patients (10%) from group b, and in no patients from group c (0%). Notably, the median number of IV BP administrations decreased after 2005. Our data confirmed a meaningful reduction of ONJ risk in MM patients treated with BPs if preventive measures are applied. Both implementation of prevention measures and reduction of cumulative doses of IV BPs could have contributed to a decreased incidence of ONJ. View Full-Text
Keywords: Bisphosphonate; pamidronate; zoledronic acid; Multiple Myeloma; Osteonecrosis of the Jaws; BRONJ; MRONJ; prevention Bisphosphonate; pamidronate; zoledronic acid; Multiple Myeloma; Osteonecrosis of the Jaws; BRONJ; MRONJ; prevention
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Catania, G.; Monaco, F.; Limberti, G.; Alessio, M.; De Martino, I.; Barile, C.; Fasciolo, A.; Baraldi, A.; Ladetto, M.; Fusco, V. Osteonecrosis of the Jaws (ONJ) after Bisphosphonate Treatment in Patients with Multiple Myeloma: Decreasing ONJ Incidence after Adoption of Preventive Measures. Dent. J. 2016, 4, 45.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Dent. J. EISSN 2304-6767 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top