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Dent. J. 2016, 4(4), 38; doi:10.3390/dj4040038

Current Controversies on the Pathogenesis of Medication-Related Osteonecrosis of the Jaw

Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
Academic Editor: Christian Walter
Received: 11 October 2016 / Revised: 11 October 2016 / Accepted: 21 October 2016 / Published: 28 October 2016
(This article belongs to the Special Issue New Cancer and Osteoporosis Therapies and Osteocrosis of the Jaws)
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Abstract

Medication-related osteonecrosis of the jaw (MRONJ) was first reported more than a decade ago. Since then, numerous cases have been diagnosed. Currently, there are three groups of drugs related to MRONJ: bisphosphonates, denosumab and anti-angiogenic drugs. As MRONJ can lead to debilitating clinical sequels and limited effective treatment options are available, much research has been done in understanding its pathophysiology. Until now, the exact pathogenesis of MRONJ has not been fully elucidated. While history of invasive dental procedures or local trauma may be present, some cases occur spontaneously without any preceding factors. This review aims to examine and discuss the three main hypotheses for the pathogenesis of MRONJ, namely suppressed bone turnover, cellular toxicity and infection. View Full-Text
Keywords: osteonecrosis of the jaw; BRONJ; MRONJ; DRONJ; bisphosphonate; zoledronate; denosumab; anti-angiogenic osteonecrosis of the jaw; BRONJ; MRONJ; DRONJ; bisphosphonate; zoledronate; denosumab; anti-angiogenic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wat, W.Z.M. Current Controversies on the Pathogenesis of Medication-Related Osteonecrosis of the Jaw. Dent. J. 2016, 4, 38.

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