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Photonics 2014, 1(4), 488-502; doi:10.3390/photonics1040488

Dental Imaging Using Mesoscopic Fluorescence Molecular Tomography: An ex Vivo Feasibility Study

1
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA
2
Department of Cariology and Comprehensive Care, New York University College of Dentistry, 345 East 24th Street, 10th Floor, New York, NY, 10010, USA
*
Author to whom correspondence should be addressed.
Received: 30 October 2014 / Revised: 27 November 2014 / Accepted: 27 November 2014 / Published: 3 December 2014
(This article belongs to the Special Issue Microwave Photonics)
View Full-Text   |   Download PDF [441 KB, uploaded 3 December 2014]   |  

Abstract

Some dental lesions are difficult to detect with traditional anatomical imaging methods, such as, with visual observation, dental radiography and X-ray computed tomography (CT). Therefore, we investigated the viability of using an optical imaging technique, Mesoscopic Fluorescence Molecular Tomography (MFMT) to retrieve molecular contrast in dental samples. To establish feasibility of obtaining 3-D images in teeth using MFMT, molecular contrast was simulated using a dye-filled capillary that was placed in the lower half of human tooth ex vivo. The dye and excitation wavelength were chosen to be excited at 650–660 nm in order to simulate a carious lesion. The location of the capillary was varied by changing the depth from the surface at which the dye, at various concentrations, was introduced. MFMT reconstructions were benchmarked against micro-CT. Overall; MFMT exhibited a location accuracy of ~15% and a volume accuracy of ~15%, up to 2 mm depth with moderate dye concentrations. These results demonstrate the potential of MFMT to retrieve molecular contrast in 3-D in highly scattering tissues, such as teeth. View Full-Text
Keywords: dental imaging; mesoscopic molecular fluorescence tomography; laminar optical tomography; Monte Carlo dental imaging; mesoscopic molecular fluorescence tomography; laminar optical tomography; Monte Carlo
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Long, F.; Ozturk, M.S.; Wolff, M.S.; Intes, X.; Kotha, S.P. Dental Imaging Using Mesoscopic Fluorescence Molecular Tomography: An ex Vivo Feasibility Study. Photonics 2014, 1, 488-502.

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