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Photonics 2014, 1(3), 220-234; doi:10.3390/photonics1030220

Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases

Nakano Eye Clinic of Kyoto Medical Co-operative, 2, Jurakumawari-Higashimachi, Nakagyo-ku, Kyoto 604-8404, Japan
Received: 20 July 2014 / Revised: 7 August 2014 / Accepted: 7 August 2014 / Published: 12 August 2014
(This article belongs to the Special Issue Optics and Technologies for Ophthalmology and Visual Science)
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Abstract

Laser speckle flowgraphy (LSFG) allows for quantitative estimation of blood flow in the optic nerve head (ONH), choroid and retina, utilizing the laser speckle phenomenon. The basic technology and clinical applications of LSFG-NAVI, the updated model of LSFG, are summarized in this review. For developing a commercial version of LSFG, the special area sensor was replaced by the ordinary charge-coupled device camera. In LSFG-NAVI, the mean blur rate (MBR) has been introduced as a new parameter. Compared to the original LSFG model, LSFG-NAVI demonstrates a better spatial resolution of the blood flow map of human ocular fundus. The observation area is 24 times larger than the original system. The analysis software can separately calculate MBRs in the blood vessels and tissues (capillaries) of an entire ONH and the measurements have good reproducibility. The absolute values of MBR in the ONH have been shown to linearly correlate with the capillary blood flow. The Analysis of MBR pulse waveform provides parameters including skew, blowout score, blowout time, rising and falling rates, flow acceleration index, acceleration time index, and resistivity index for comparing different eyes. Recently, there have been an increasing number of reports on the clinical applications of LSFG-NAVI to ocular diseases, including glaucoma, retinal and choroidal diseases. View Full-Text
Keywords: laser speckle flowgraphy; LSFG-NAVI; mean blur rate; glaucoma; retinal and choroidal diseases laser speckle flowgraphy; LSFG-NAVI; mean blur rate; glaucoma; retinal and choroidal diseases
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sugiyama, T. Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases. Photonics 2014, 1, 220-234.

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