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Separations 2016, 3(1), 7; doi:10.3390/chromatography3010007

Application of Carbon Nanotubes Modified Coatings for the Determination of Amphetamines by In-Tube Solid-Phase Microextraction and Capillary Liquid Chromatography

Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, Burjassot, Valencia 46100, Spain
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Academic Editor: Victoria F. Samanidou
Received: 17 December 2015 / Accepted: 6 February 2016 / Published: 1 March 2016
(This article belongs to the Special Issue Trends in Microextraction Techniques for Sample Preparation)
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Abstract

In this study, polydimethylsiloxane (PDMS)-coated capillary columns (TRB-5 and TRB-35), both unmodified and functionalized with single-wall carbon nanotubes (SWCNTs) or multiwall carbon nanotubes (MWCNTs), have been tested and compared for the extraction of amphetamine (AMP), methamphetamine (MET) and ephedrine (EPE) by in-tube solid-phase microextraction (IT-SPME). Prior to their extraction, the analytes were derivatized with the fluorogenic reagent 9-fluorenylmethyl chloroformate (FMOC). For separation and detection capillary chromatography with fluorimetric detection has been used. The presence of carbon nanotubes in the extractive coatings enhanced the extraction efficiencies and also significantly improved the chromatographic profiles, thus resulting in a reliable option for the analysis of these drugs. As an example of application, a new method is proposed for the analysis of the tested amphetamines in oral fluid using a TRB-35 capillary column functionalized with MWCNTs. The proposed conditions provided suitable selectivity and reproducibility (CV ≤ 6%, n = 3) at low µg/mL levels, and limits of detection of 0.5–0.8 µg/mL. View Full-Text
Keywords: carbon nanotubes (CNTs); in-tube solid-phase microextraction (IT-SPME); derivatization; amphetamines; capillary liquid chromatography carbon nanotubes (CNTs); in-tube solid-phase microextraction (IT-SPME); derivatization; amphetamines; capillary liquid chromatography
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Argente-García, A.I.; Moliner-Martínez, Y.; López-García, E.; Campíns-Falcó, P.; Herráez-Hernández, R. Application of Carbon Nanotubes Modified Coatings for the Determination of Amphetamines by In-Tube Solid-Phase Microextraction and Capillary Liquid Chromatography. Separations 2016, 3, 7.

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