Table of Contents
Processes, Volume 6, Issue 8 (August 2018)
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Cover Story (view full-size image) Kinetic modeling of metabolic reaction networks requires knowledge of parameters associated with [...] Read more. Kinetic modeling of metabolic reaction networks requires knowledge of parameters associated with every reaction in the network, including potential regulatory molecular players. Cybernetic modeling overcomes this requirement by accounting for regulation through the incorporation of the cybernetic variables, ui and vi, calculated to satisfy cellular objectives. While past cybernetic models have relied on objectives such as maximizing growth rate or carbon uptake rate, the framework here is adapted to model the dynamic behavior of biosynthesis of the inflammatory molecule prostaglandin based on maximizing the inflammatory marker cytokine, TNFα, in macrophage cells. This captures the inflammatory response to infection in bone marrow-derived macrophage cells. View this paper.