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Processes, Volume 5, Issue 2

2017 June - 19 articles

Cover Story: “Physiologically relevant” in vitro models are designed to better mimic in vivo conditions. Besides flow and 3D architecture, they also require the control of environmental parameters to ensure that the in vivo physico-chemical milieu is recapitulated. The SUITE platform – consisting of a pump, modular bioreactors and a mixing chamber, along with sensing, actuation, and control components – was engineered as a free-standing fluidic cell culture system able to measure and regulate cell culture parameters (e.g. temperature, pH, pressure) “on-line”. SUITE can be used for generating pathophysiological biomimetic in-vitro models, with applications in disease modelling or toxicity testing. View this paper
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Articles (19)

  • Article
  • Open Access
16 Citations
10,345 Views
31 Pages

19 June 2017

Metabolic acclimation to photosynthesis-associated stresses was examined in the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1 using integrated computational and photobioreactor analyses. A genome-enabled metabolic model, complete wit...

(This article belongs to the Special Issue Microbial Community Modeling: Prediction of Microbial Interactions and Community Dynamics)
  • Editorial
  • Open Access
6 Citations
5,796 Views
4 Pages

17 June 2017

This Special Issue (SI) of Processes on water soluble polymers (WSP), and the associated Special Issue reprint, contain papers that deal with this extremely popular area of scientific investigation in polymer science and engineering, both in academic...

(This article belongs to the Special Issue Water Soluble Polymers)
  • Article
  • Open Access
3 Citations
7,736 Views
20 Pages

Closed-Loop Characterization of Neuronal Activation Using Electrical Stimulation and Optical Imaging

  • Michelle L. Kuykendal,
  • Gareth S. Guvanasen,
  • Steve M. Potter,
  • Martha A. Grover and
  • Stephen P. DeWeerth

3 June 2017

We have developed a closed-loop, high-throughput system that applies electrical stimulation and optical recording to facilitate the rapid characterization of extracellular, stimulus-evoked neuronal activity. In our system, a microelectrode array deli...

  • Feature Paper
  • Article
  • Open Access
26 Citations
8,230 Views
16 Pages

2 June 2017

Abstract: Dynamic modelling is a powerful tool for studying biological networks. Reachability (controllability), observability, and structural identifiability are classical system-theoretic properties of dynamical models. A model is structurally iden...

(This article belongs to the Special Issue Biological Networks)
  • Feature Paper
  • Article
  • Open Access
9 Citations
10,326 Views
17 Pages

31 May 2017

In chemical industries, process operations are usually comprised of several discrete operating regions with distributions that drift over time. These complexities complicate outlier detection in the presence of intrinsic process dynamics. In this art...

(This article belongs to the Collection Process Data Analytics)
  • Feature Paper
  • Article
  • Open Access
14 Citations
8,151 Views
23 Pages

Comparison of Polymer Networks Synthesized by Conventional Free Radical and RAFT Copolymerization Processes in Supercritical Carbon Dioxide

  • Patricia Pérez-Salinas,
  • Gabriel Jaramillo-Soto,
  • Alberto Rosas-Aburto,
  • Humberto Vázquez-Torres and ,
  • María Josefa Bernad-Bernad,
  • Ángel Licea-Claverie and
  • Eduardo Vivaldo-Lima
  • + 2 authors+ 0 author

9 May 2017

There is a debate in the literature on whether or not polymer networks synthesized by reversible deactivation radical polymerization (RDRP) processes, such as reversible addition-fragmentation radical transfer (RAFT) copolymerization of vinyl/divinyl...

(This article belongs to the Special Issue Water Soluble Polymers)
  • Article
  • Open Access
21 Citations
8,733 Views
15 Pages

Design of Cross-Linked Starch Nanocapsules for Enzyme-Triggered Release of Hydrophilic Compounds

  • Fernanda R. Steinmacher,
  • Grit Baier,
  • Anna Musyanovych,
  • Katharina Landfester and ,
  • Pedro H. H. Araújo and
  • Claudia Sayer
  • + 1 author+ 0 author

6 May 2017

Cross-linked starch nanocapsules (NCs) were synthesized by interfacial polymerization carried out using the inverse mini-emulsion technique. 2,4-toluene diisocyanate (TDI) was used as the cross-linker. The influence of TDI concentrations on the polym...

(This article belongs to the Special Issue Water Soluble Polymers)
  • Review
  • Open Access
61 Citations
15,898 Views
27 Pages

Applications of Water-Soluble Polymers in Turbulent Drag Reduction

  • Wen Jiao Han,
  • Yu Zhen Dong and
  • Hyoung Jin Choi

4 May 2017

Water-soluble polymers with high molecular weights are known to decrease the frictional drag in turbulent flow very effectively at concentrations of tens or hundreds of ppm. This drag reduction efficiency of water-soluble polymers is well known to be...

(This article belongs to the Special Issue Water Soluble Polymers)
  • Feature Paper
  • Article
  • Open Access
20 Citations
11,838 Views
18 Pages

27 April 2017

Water-soluble, carboxylic acid monomers are known to exhibit peculiar kinetics when polymerized in aqueous solution. Namely, their free-radical polymerization rate is affected by several parameters such as monomer concentration, ionic strength, and p...

(This article belongs to the Special Issue Water Soluble Polymers)
  • Article
  • Open Access
39 Citations
15,006 Views
22 Pages

Analyzing the Mixing Dynamics of an Industrial Batch Bin Blender via Discrete Element Modeling Method

  • Maitraye Sen,
  • Subhodh Karkala,
  • Savitha Panikar,
  • Olav Lyngberg and ,
  • Mark Johnson,
  • Alexander Marchut,
  • Elisäbeth Schäfer and
  • Rohit Ramachandran
  • + 3 authors+ 0 author

25 April 2017

A discrete element model (DEM) has been developed for an industrial batch bin blender in which three different types of materials are mixed. The mixing dynamics have been evaluated from a model-based study with respect to the blend critical quality a...

  • Article
  • Open Access
48 Citations
16,428 Views
19 Pages

24 April 2017

Hydrogels based on poly(2-hydroxyethyl methacrylate) (PHEMA) are a very important class of biomaterials with several applications mainly in tissue engineering and contacts lenses. Although the polymerization kinetics of HEMA have been investigated in...

(This article belongs to the Special Issue Water Soluble Polymers)
  • Article
  • Open Access
11 Citations
9,500 Views
15 Pages

20 April 2017

A series of PDLLA-PEG1k-PDLLA tri-block co-polymers with various compositions, i.e., containing 2–10 lactoyl units, were prepared via ring opening polymerisation of d,l-lactide in the presence of poly (ethylene glycol) (PEG) (Mn = 1000 g·mol−1) as th...

(This article belongs to the Special Issue Water Soluble Polymers)
  • Feature Paper
  • Perspective
  • Open Access
99 Citations
28,532 Views
13 Pages

20 April 2017

While many perceive mammalian cell culture-based manufacturing for biopharmaceuticals an established technology, numerous open questions remain to be solved. Genetic diversity and mutation rates in CHO cells have been underestimated since progeny of...

  • Feature Paper
  • Article
  • Open Access
28 Citations
11,808 Views
14 Pages

20 April 2017

An in situ nuclear magnetic resonance spectroscopy (NMR) technique is used to monitor the aqueous-phase copolymerization kinetics of methacrylic acid (MAA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) macromonomers. In particular, the...

(This article belongs to the Special Issue Water Soluble Polymers)
  • Article
  • Open Access
2 Citations
5,831 Views
14 Pages

11 April 2017

A new Automatic Continuous Online Monitoring of Polymerization reactions (ACOMP) system has been developed with multiple light scattering and viscosity detection stages in serial flow, where solution conditions are different at each stage. Solution c...

(This article belongs to the Special Issue Water Soluble Polymers)
  • Article
  • Open Access
20 Citations
12,026 Views
15 Pages

Environmental Control in Flow Bioreactors

  • Serena Giusti,
  • Daniele Mazzei,
  • Ludovica Cacopardo,
  • Giorgio Mattei and ,
  • Claudio Domenici and
  • Arti Ahluwalia
  • + 1 author+ 0 author

7 April 2017

The realization of physiologically-relevant advanced in vitro models is not just related to the reproduction of a three-dimensional multicellular architecture, but also to the maintenance of a cell culture environment in which parameters, such as tem...

(This article belongs to the Special Issue Biomedical Systems Control)
  • Article
  • Open Access
5 Citations
8,429 Views
15 Pages

Targeted Stimulation Using Differences in Activation Probability across the Strength–Duration Space

  • Michelle L. Kuykendal,
  • Steve M. Potter,
  • Martha A. Grover and
  • Stephen P. DeWeerth

24 March 2017

Electrical stimulation is ubiquitous as a method for activating neuronal tissue, but there is still significant room for advancement in the ability of these electrical devices to implement smart stimulus waveform design to more selectively target pop...

  • Feature Paper
  • Article
  • Open Access
14 Citations
6,550 Views
12 Pages

24 March 2017

Background: Magnetic fields can interact with liquid matter in a homogeneous and instantaneous way, without physical contact, independently of its temperature, pressure, and agitation degree, and without modifying recipes nor heat and mass transfer c...

(This article belongs to the Special Issue Water Soluble Polymers)
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Processes - ISSN 2227-9717