Next Article in Journal / Special Issue
Modeling and Hemofiltration Treatment of Acute Inflammation
Previous Article in Journal
Process Intensification in Fuel Cell CHP Systems, the ReforCELL Project
Previous Article in Special Issue
Embedded Control in Wearable Medical Devices: Application to the Artificial Pancreas
Article Menu

Export Article

Open AccessFeature PaperReview
Processes 2016, 4(4), 39; doi:10.3390/pr4040039

Algorithms for a Single Hormone Closed-Loop Artificial Pancreas: Challenges Pertinent to Chemical Process Operations and Control

1
Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 Eighth St., Troy, NY 12180-3590, USA
2
Stanford University, 780 Welch Road, CJ320H MC 5776, Palo Alto, CA 94304, USA
3
Barbara Davis Center for Diabetes, University of Colorado, Denver, 1775 Aurora Court, Aurora, CO 80045, USA
4
Icahn School of Medicine at Mt. Sinai, 1 Gustave A. Levy Place, New York, NY 10029, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Henson
Received: 6 September 2016 / Revised: 30 September 2016 / Accepted: 8 October 2016 / Published: 18 October 2016
(This article belongs to the Special Issue Biomedical Systems Control)
View Full-Text   |   Download PDF [1701 KB, uploaded 8 November 2016]   |  

Abstract

The development of a closed-loop artificial pancreas to regulate the blood glucose concentration of individuals with type 1 diabetes has been a focused area of research for over 50 years, with rapid progress during the past decade. The daily control challenges faced by someone with type 1 diabetes include asymmetric objectives and risks, and one-sided manipulated input action with frequent relatively fast disturbances. The major automation steps toward a closed-loop artificial pancreas include (i) monitoring and overnight alarms for hypoglycemia (low blood glucose); (ii) overnight low glucose suspend (LGS) systems to prevent hypoglycemia; and (iii) fully closed-loop systems that adjust insulin (and perhaps glucagon) to maintain desired blood glucose levels day and night. We focus on the steps that we used to develop and test a probabilistic, risk-based, model predictive control strategy for a fully closed-loop artificial pancreas. We complete the paper by discussing ramifications of lessons learned for chemical process systems applications. View Full-Text
Keywords: artificial pancreas; glucose control; type 1 diabetes artificial pancreas; glucose control; type 1 diabetes
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bequette, B.W.; Cameron, F.; Baysal, N.; Howsmon, D.P.; Buckingham, B.A.; Maahs, D.M.; Levy, C.J. Algorithms for a Single Hormone Closed-Loop Artificial Pancreas: Challenges Pertinent to Chemical Process Operations and Control. Processes 2016, 4, 39.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Processes EISSN 2227-9717 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top