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Children 2014, 1(1), 48-62; doi:10.3390/children1010048
Review

Endocrine Disorders in Childhood Cancer Survivors Treated with Haemopoietic Stem Cell Transplantation

1
 and
1,2,*
Received: 22 May 2014 / Revised: 17 June 2014 / Accepted: 18 June 2014 / Published: 23 June 2014
(This article belongs to the Special Issue Acute and Long-Term Sequelae of Childhood Cancer Therapy)
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Abstract

The increasing number of haemopoietic stem cell transplantations (HSCT) taking place worldwide has offered a cure to many high risk childhood malignancies with an otherwise very poor prognosis. However, HSCT is associated with an increased risk of morbidity and premature death, and patients who have survived the acute complications continue to face lifelong health sequelae as a result of the treatment. Endocrine dysfunction is well described in childhood HSCT survivors treated for malignancies. The endocrine system is highly susceptible to damage from the conditioning therapy, such as, alkylating agents and total body irradiation, which is given prior stem cell infusion. Although not immediately life-threatening, the impact of these abnormalities on the long term health and quality of life in these patients may be considerable. The prevalence, risk factors, clinical approaches to investigations and treatments, as well as the implications of ongoing surveillance of endocrine disorders in childhood HSCT survivors, are discussed in this review.
Keywords: haemopoietic stem cell transplantation; endocrine disorders; growth hormone deficiency; hypothyroidism; gonadal failure haemopoietic stem cell transplantation; endocrine disorders; growth hormone deficiency; hypothyroidism; gonadal failure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wei, C.; Albanese, A. Endocrine Disorders in Childhood Cancer Survivors Treated with Haemopoietic Stem Cell Transplantation. Children 2014, 1, 48-62.

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