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Children 2014, 1(1), 40-47; doi:10.3390/children1010040

Controversies Surrounding Clostridium difficile Infection in Infants and Young Children

1,* , 2
Received: 14 April 2014 / Accepted: 26 May 2014 / Published: 13 June 2014
(This article belongs to the Special Issue Controversies in Pediatric Digestive Diseases)
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Clostridium difficile is a frequent cause of antibiotic-associated diarrhea in adults and older children. However, as many as 80% of infants can be asymptomatically colonized. The reasons for this have not been well established but are believed to be due to differences in toxin receptors or toxin internalization. Determining which children who test positive for C. difficile warrant treatment is exceedingly difficult, especially in the setting of increased rates of detection and the rising risk of disease in children lacking classic risk factors for C. difficile.
Keywords: Clostridium difficile; colonization; neonates; diarrhea Clostridium difficile; colonization; neonates; diarrhea
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nicholson, M.R.; Thomsen, I.P.; Edwards, K.M. Controversies Surrounding Clostridium difficile Infection in Infants and Young Children. Children 2014, 1, 40-47.

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