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Children 2014, 1(2), 63-73; doi:10.3390/children1020063

Predicting Adverse Health Outcomes in Long-Term Survivors of a Childhood Cancer

1
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd Street, New York, NY 10065, USA
2
Departments of Medicine and Pediatrics, Memorial Sloan Kettering Cancer Center, 300 E 66th Street, 9th Floor, New York, NY 10065, USA
*
Author to whom correspondence should be addressed.
Received: 2 June 2014 / Revised: 4 July 2014 / Accepted: 7 July 2014 / Published: 15 July 2014
(This article belongs to the Special Issue Acute and Long-Term Sequelae of Childhood Cancer Therapy)
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Abstract

More than 80% of children and young adults diagnosed with invasive cancer will survive five or more years beyond their cancer diagnosis. This population has an increased risk for serious illness- and treatment-related morbidity and premature mortality. A number of these adverse health outcomes, such as cardiovascular disease and some second primary neoplasms, either have modifiable risk factors or can be successfully treated if detected early. Absolute risk models that project a personalized risk of developing a health outcome can be useful in patient counseling, in designing intervention studies, in forming prevention strategies, and in deciding upon surveillance programs. Here, we review existing absolute risk prediction models that are directly applicable to survivors of a childhood cancer, discuss the concepts and interpretation of absolute risk models, and examine ways in which these models can be used applied in clinical practice and public health. View Full-Text
Keywords: clinical prediction tool, risk prediction model, late effects, second cancers clinical prediction tool, risk prediction model, late effects, second cancers
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MDPI and ACS Style

Moskowitz, C.S.; Oeffinger, K.C. Predicting Adverse Health Outcomes in Long-Term Survivors of a Childhood Cancer. Children 2014, 1, 63-73.

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