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Biomedicines 2018, 6(2), 43; https://doi.org/10.3390/biomedicines6020043

The Many Roles of Ubiquitin in NF-κB Signaling

INSERM U1038/BGE/BIG, CEA Grenoble, 38054 Grenoble, France
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Received: 15 March 2018 / Revised: 31 March 2018 / Accepted: 2 April 2018 / Published: 10 April 2018
(This article belongs to the Special Issue Roles of NF-κB in Cancer and Their Therapeutic Approaches)
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Abstract

The nuclear factor κB (NF-κB) signaling pathway ubiquitously controls cell growth and survival in basic conditions as well as rapid resetting of cellular functions following environment changes or pathogenic insults. Moreover, its deregulation is frequently observed during cell transformation, chronic inflammation or autoimmunity. Understanding how it is properly regulated therefore is a prerequisite to managing these adverse situations. Over the last years evidence has accumulated showing that ubiquitination is a key process in NF-κB activation and its resolution. Here, we examine the various functions of ubiquitin in NF-κB signaling and more specifically, how it controls signal transduction at the molecular level and impacts in vivo on NF-κB regulated cellular processes. View Full-Text
Keywords: nuclear factor κB; signal transduction; ubiquitin; ubiquitination/deubiquitination nuclear factor κB; signal transduction; ubiquitin; ubiquitination/deubiquitination
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Courtois, G.; Fauvarque, M.-O. The Many Roles of Ubiquitin in NF-κB Signaling. Biomedicines 2018, 6, 43.

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