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Biomedicines 2018, 6(2), 42; https://doi.org/10.3390/biomedicines6020042

Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells

1
and
1,2,3,*
1
Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
2
Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH 44195, USA
3
Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
*
Author to whom correspondence should be addressed.
Received: 3 March 2018 / Revised: 27 March 2018 / Accepted: 3 April 2018 / Published: 8 April 2018
(This article belongs to the Special Issue Stem Cells and Cancer Therapeutics)
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Abstract

Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins. Besides their role in development, semaphorin signaling may promote or suppress tumors depending on their context. Sema3C is a secreted semaphorin that plays an important role in the maintenance of cancer stem-like cells, promotes migration and invasion, and may facilitate angiogenesis. Therapeutic strategies that inhibit Sema3C signaling may improve cancer control. This review will summarize the current research on the Sema3C pathway and its potential as a therapeutic target. View Full-Text
Keywords: semaphorin; plexin; neuropilin; Sema3C; Semaphorin 3C; cancer stem cell; glioma stem cell; invasion; migration; angiogenesis; neurodevelopment; axon guidance; glioma; glioblastoma; cancer semaphorin; plexin; neuropilin; Sema3C; Semaphorin 3C; cancer stem cell; glioma stem cell; invasion; migration; angiogenesis; neurodevelopment; axon guidance; glioma; glioblastoma; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Hao, J.; Yu, J.S. Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells. Biomedicines 2018, 6, 42.

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