Special Issue "Stem Cells and Cancer Therapeutics"
A special issue of Biomedicines (ISSN 2227-9059).
Deadline for manuscript submissions: 30 September 2018
Stems cells are defined as cells with the ability to self-renew and to differentiate into multiple lineages. This definition applies to both physiologic and pathologic conditions such as cancer, although functional differences in these cell populations crucially impact on their behavior. In the case of cancer, multiple experimental evidences support the existence of specific cell populations that are functionally identified for their capacity to initiate and propagate tumors. These cells have been classically called tumor initiating cells (TICs) or cancer stem cells (CSCs) and are supposed to possess stem cell-like properties, including long-term self-renewal, capacity of multi-lineage differentiation, increased resistance to therapy, and the ability to promote tumor relapse and metastasis. As in normal stem cells, essential developmental related pathways such as Wnt, Notch, Hedgehog, NF-kappaB, or JAK/STAT participate in supporting TIC capacity. This special issue will focus on understanding the molecular mechanisms that control normal and cancer-related stemness and the tools that are currently available for studying them both in vitro and in vivo. In particular, we will pay attention in how TICs contribute to cancer progression and therapy resistance, and the possibility of specifically targeting TIC in anti-cancer therapies.
Dr. Anna Vert
Dr. Lluis Espinosa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Signaling pathways in normal and tumor stem cells
- Cancer stem cells and their biology
- Stem cells and metastasis
- In vivo models for studying normal and cancer stem cells
- In vitro models for studying normal and cancer stem cells
- Targeting cancer stem cells
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Gastrointestinal Epithelial Stem Cell and Cellular Origin of Cancer
Authors: Masahiro Hata, Yoku Hayakawa, Kazuhiko Koike
Abstract: Several stem cell markers within gastrointestinal epithelium have been identified by using mouse models. Lgr5 is one of the best characterized stem cell markers, and evidence suggest that Lgr5+ cells in the gut serve as origins of gastrointestinal cancers. There are also reserve or facultative stem or progenitor cells which can interconvert to Lgr5+ cells following injury. Compared to the intestine where Lgr5+ cells at crypt base act as active stem cells, the stomach may have unique and distinct stem cell populations, since gastric Lgr5+ cells likely behave as reserve stem cells rather than active stem cells both in the corpus and antral glands. Gastrointestinal stem cells are supported by specified microenvironment that is called as stem cell niche, which also promotes the process of tumorigenesis. Here, we review and summarize the reported stem cell markers in the gut and supporting niche factors, and highlight the molecular mechanism that regulates stem cell function and tumorigenesis.