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Biomedicines 2017, 5(3), 35; doi:10.3390/biomedicines5030035

Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease

1
Division of Hematology and Oncology, University of Kansas Cancer Center, Kansas City, KS 66205, USA
2
Division of Hematology, Oncology and Blood and Marrow Transplantation, Children’s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA
3
Section of Blood and Marrow Transplantation and Cellular Therapy, University of Alabama at Birmingham, Brimingham, AL 35294, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 23 May 2017 / Revised: 15 June 2017 / Accepted: 18 June 2017 / Published: 26 June 2017
(This article belongs to the Special Issue Cell Therapy for the Treatment of GVHD)
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Abstract

Graft versus host disease (GVHD) represents a major complication of allogeneic hematopoietic stem cell transplantation (allo HCT). Graft cellular manipulation has been used to mitigate the risk of GVHD. The αβ T cells are considered the primary culprit for causing GVHD therefore depletion of this T cell subset emerged as a promising cellular manipulation strategy to overcome the human leukocyte antigen (HLA) barrier of haploidentical (haplo) HCT. This approach is also being investigated in HLA-matched HCT. In several studies, αβ T cell depletion HCT has been performed without pharmacologic GVHD prophylaxis, thus unleashing favorable effect of donor’s natural killer cells (NK) and γδ T cells. This article will discuss the evolution of this method in clinical practice and the clinical outcome as described in different clinical trials. View Full-Text
Keywords: αβ T cells; haploidentical transplant; graft versus host disease αβ T cells; haploidentical transplant; graft versus host disease
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Abdelhakim, H.; Abdel-Azim, H.; Saad, A. Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease. Biomedicines 2017, 5, 35.

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