Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease
AbstractGraft versus host disease (GVHD) represents a major complication of allogeneic hematopoietic stem cell transplantation (allo HCT). Graft cellular manipulation has been used to mitigate the risk of GVHD. The αβ T cells are considered the primary culprit for causing GVHD therefore depletion of this T cell subset emerged as a promising cellular manipulation strategy to overcome the human leukocyte antigen (HLA) barrier of haploidentical (haplo) HCT. This approach is also being investigated in HLA-matched HCT. In several studies, αβ T cell depletion HCT has been performed without pharmacologic GVHD prophylaxis, thus unleashing favorable effect of donor’s natural killer cells (NK) and γδ T cells. This article will discuss the evolution of this method in clinical practice and the clinical outcome as described in different clinical trials. View Full-Text
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Abdelhakim, H.; Abdel-Azim, H.; Saad, A. Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease. Biomedicines 2017, 5, 35.
Abdelhakim H, Abdel-Azim H, Saad A. Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease. Biomedicines. 2017; 5(3):35.Chicago/Turabian Style
Abdelhakim, Haitham; Abdel-Azim, Hisham; Saad, Ayman. 2017. "Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease." Biomedicines 5, no. 3: 35.
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