Next Article in Journal
Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease
Previous Article in Journal
T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation
Article Menu

Export Article

Open AccessReview
Biomedicines 2017, 5(2), 34; doi:10.3390/biomedicines5020034

The Role of Angiogenesis in Cancer Treatment

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA
*
Author to whom correspondence should be addressed.
Received: 2 May 2017 / Revised: 9 June 2017 / Accepted: 15 June 2017 / Published: 21 June 2017
(This article belongs to the Special Issue Anti-Angiogenesis Therapeutics in Cancer)
View Full-Text   |   Download PDF [745 KB, uploaded 22 June 2017]   |  

Abstract

A number of anti-angiogenesis drugs have been FDA-approved and are being used in cancer treatment, and a number of other agents are in different stages of clinical development or in preclinical evaluation. However, pharmacologic anti-angiogenesis strategies that arrest tumor progression might not be enough to eradicate tumors. Decreased anti-angiogenesis activity in single mechanism-based anti-angiogenic strategies is due to the redundancy, multiplicity, and development of compensatory mechanism by which blood vessels are remodeled. Improving anti-angiogenesis drug efficacy will require identification of broad-spectrum anti-angiogenesis targets. These strategies may have novel features, such as increased porosity, and are the result of complex interactions among endothelial cells, extracellular matrix proteins, growth factors, pericyte, and smooth muscle cells. Thus, combinations of anti-angiogenic drugs and other anticancer strategies such as chemotherapy appear essential for optimal outcome in cancer patients. This review will focus on the role of anti-angiogenesis strategies in cancer treatment. View Full-Text
Keywords: physiological angiogenesis; pathological angiogenesis; pro-angiogenesis; anti-angiogenesis; endothelial cells; pericyte; integrin; matrix metalloproteinase; vascular growth factors; anti-VEGF; anti-integrin; tyrosine kinase inhibitors physiological angiogenesis; pathological angiogenesis; pro-angiogenesis; anti-angiogenesis; endothelial cells; pericyte; integrin; matrix metalloproteinase; vascular growth factors; anti-VEGF; anti-integrin; tyrosine kinase inhibitors
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Rajabi, M.; Mousa, S.A. The Role of Angiogenesis in Cancer Treatment. Biomedicines 2017, 5, 34.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomedicines EISSN 2227-9059 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top