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Biomedicines 2017, 5(2), 33; doi:10.3390/biomedicines5020033

T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation

John van Geest Cancer Research Centre, Nottingham Trent University, Clifton Lane NG11 8NS, UK
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Received: 8 April 2017 / Revised: 16 June 2017 / Accepted: 19 June 2017 / Published: 21 June 2017
(This article belongs to the Special Issue Cell Therapy for the Treatment of GVHD)
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Abstract

Allogeneic haematopoietic stem cell transplantation (HSCT) from an human leukocyte antigen (HLA)-identical donor can be curative for eligible patients with non-malignant and malignant haematological disorders. HSCT from alternative donor sources, such as HLA-mismatched haploidentical donors, is increasingly considered as a viable therapeutic option for patients lacking HLA-matched donors. Initial attempts at haploidentical HSCT were associated with vigorous bidirectional alloreactivity, leading to unacceptably high rates of graft rejection and graft-versus-host disease (GVHD). More recently, new approaches for mitigating harmful T-cell alloreactivity that mediates GVHD, while preserving the function of tumour-reactive natural killer (NK) cells and γδ T cells, have led to markedly improved clinical outcomes, and are successfully being implemented in the clinic. This article will provide an update on in vitro strategies and in vivo approaches aimed at preventing GVHD by selectively manipulating key components of the adaptive immune response, such as T-cell receptor (TCR)-αβ T cells and CD45RA-expressing naive T cells. View Full-Text
Keywords: graft-versus-host disease; haploidentical haematopoietic stem cell transplantation; regulatory T cells; immunomagnetic T-cell depletion; photodynamic purging; dendritic cells graft-versus-host disease; haploidentical haematopoietic stem cell transplantation; regulatory T cells; immunomagnetic T-cell depletion; photodynamic purging; dendritic cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vadakekolathu, J.; Rutella, S. T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation. Biomedicines 2017, 5, 33.

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