Biomedicines 2013, 1(1), 49-78; doi:10.3390/biomedicines1010049
Review

Decoding the Pluripotency Network: The Emergence of New Transcription Factors

1email, 1email and 1,2,* email
Received: 23 October 2013; in revised form: 10 December 2013 / Accepted: 11 December 2013 / Published: 16 December 2013
(This article belongs to the Special Issue Feature Papers)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Since the successful isolation of mouse and human embryonic stem cells (ESCs) in the past decades, massive investigations have been conducted to dissect the pluripotency network that governs the ability of these cells to differentiate into all cell types. Beside the core Oct4-Sox2-Nanog circuitry, accumulating regulators, including transcription factors, epigenetic modifiers, microRNA and signaling molecules have also been found to play important roles in preserving pluripotency. Among the various regulations that orchestrate the cellular pluripotency program, transcriptional regulation is situated in the central position and appears to be dominant over other regulatory controls. In this review, we would like to summarize the recent advancements in the accumulating findings of new transcription factors that play a critical role in controlling both pluripotency network and ESC identity.
Keywords: pluripotency; embryonic stem cell; transcriptional network; transcription factor
PDF Full-text Download PDF Full-Text [275 KB, uploaded 16 December 2013 18:47 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Lee, K.C.; Wong, W.K.; Feng, B. Decoding the Pluripotency Network: The Emergence of New Transcription Factors. Biomedicines 2013, 1, 49-78.

AMA Style

Lee KC, Wong WK, Feng B. Decoding the Pluripotency Network: The Emergence of New Transcription Factors. Biomedicines. 2013; 1(1):49-78.

Chicago/Turabian Style

Lee, Kai C.; Wong, Wing K.; Feng, Bo. 2013. "Decoding the Pluripotency Network: The Emergence of New Transcription Factors." Biomedicines 1, no. 1: 49-78.

Biomedicines EISSN 2227-9059 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert