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Biomedicines 2013, 1(1), 17-48; doi:10.3390/biomedicines1010017
Review

PTEN, Longevity and Age-Related Diseases

1
, 1,2,3
 and 1,2,3,4,*
1 School of Applied Sciences, Auckland University of Technology, WS306, WS Building, City Campus, St Paul Street, Auckland 1010, New Zealand 2 School of Interprofessional Health Studies, Auckland University of Technology, AF Building, North Shore Campus, 90 Akoranga Drive, Auckland 0627, New Zealand 3 Institute for Applied Ecology New Zealand, Auckland University of Technology, WL Building, City Campus, St Paul Street, Auckland 1010, New Zealand 4 Institute of Biomedical Technology, Auckland University of Technology, WD Building, City Campus, St Paul Street, Auckland 1010, New Zealand
* Author to whom correspondence should be addressed.
Received: 4 November 2013 / Revised: 26 November 2013 / Accepted: 9 December 2013 / Published: 13 December 2013
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Abstract

Since the discovery of PTEN, this protein has been shown to be an effective suppressor of cancer and a contributor to longevity. This report will review, in depth, the associations between PTEN and other molecules, its mutations and regulations in order to present how PTEN can be used to increase longevity. This report will collect recent research of PTEN and use this to discuss PTEN’s role in caloric restriction, antioxidative defense of DNA-damage and the role it plays in suppressing tumors. The report will also discuss that variety of ways that PTEN can be compromised, through mutations, complete loss of alleles and its main antagonist, the PI3K/AKT pathway.
Keywords: PTEN; aging; longevity; caloric; restriction; DNA; damage; gene PTEN; aging; longevity; caloric; restriction; DNA; damage; gene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tait, I.S.; Li, Y.; Lu, J. PTEN, Longevity and Age-Related Diseases. Biomedicines 2013, 1, 17-48.

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