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Chemosensors 2017, 5(3), 25; doi:10.3390/chemosensors5030025

Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid

1
Laboratorio de Electroquímica del Medio Ambiente, Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile, USACh, Casilla 40, Correo 33, Santiago 71783-5, Chile
2
Departament d’Enginyeria Química i Química Analítica, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, E-08028 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Received: 20 July 2017 / Revised: 6 September 2017 / Accepted: 13 September 2017 / Published: 17 September 2017
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Abstract

This work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydrochlorothiazide (HCTZ) by differential pulse voltammetry. Both electrochemical characterization and analytical performance indicate that SPCE/EGA is a much better sensor for HCTZ. The detection and quantification limits were at the level of μmol L−1 with a very good linearity in the studied concentration range. In addition, the proposed SPCE/EGA was successfully applied for the determination of HCTZ in an anti-hypertensive drug with high reproducibility and good trueness. View Full-Text
Keywords: glutamic acid-modified screen-printed electrode; voltammetry; electropolymerization; electrografting; hydrochlorothiazide determination glutamic acid-modified screen-printed electrode; voltammetry; electropolymerization; electrografting; hydrochlorothiazide determination
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González-Vargas, C.; Serrano, N.; Ariño, C.; Salazar, R.; Esteban, M.; Díaz-Cruz, J.M. Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid. Chemosensors 2017, 5, 25.

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