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Chemosensors 2014, 2(1), 1-12; doi:10.3390/chemosensors2010001
Article

Swelling Properties of Hydrogels Containing Phenylboronic Acids

1,†
, 1,†
 and 1,2,*
Received: 15 October 2013; in revised form: 19 November 2013 / Accepted: 12 December 2013 / Published: 30 December 2013
(This article belongs to the Special Issue Hydrogel-Based Chemosensors)
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Abstract: Phenylboronic acids are a class of compounds that bind glucose and other sugars. When polymerized into hydrogels, they provide a convenient nonenzymatic means for sensing glucose concentration, provided competing sugars are present at negligible concentrations. In this paper we provide a comprehensive study of swelling of hydrogels containing methacrylamidophenylboronic acid (MPBA), as a function of pH and concentration of either glucose or fructose. In one set of hydrogels, MPBA is substituted at 20 mol·% in a polyacrylamide hydrogel [p(MPBA-co-AAm)], while in a second set of hydrogels, 20 mol·% MPBA is supplemented with 20 mol·% of N-3-(dimethylaminopropyl methacrylamide) [p(MPBA-co-DMP-co-AAm)]. Swelling curves are markedly different for fructose and glucose, and for the two sets of hydrogels. While fructose alters swelling by binding and contributing to the ionization of MPBA, glucose does the same, but it also can form crosslinking bridges between separate chains, leading to hydrogel shrinkage. While the [p(MPBA-co-AAm)] hydrogels behaved as polyacids, swelling monotonically with increasing pH, the [p(MPBA-co-DMP-co-AAm)] hydrogels exhibited polyampholyte behavior, with swelling minima at intermediate pH values.
Keywords: hydrogels; glucose sensing; polyelectrolyte; polyampholyte; Donnan osmotic pressure; phenylboronic acid hydrogels; glucose sensing; polyelectrolyte; polyampholyte; Donnan osmotic pressure; phenylboronic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kim, A.; Mujumdar, S.K.; Siegel, R.A. Swelling Properties of Hydrogels Containing Phenylboronic Acids. Chemosensors 2014, 2, 1-12.

AMA Style

Kim A, Mujumdar SK, Siegel RA. Swelling Properties of Hydrogels Containing Phenylboronic Acids. Chemosensors. 2014; 2(1):1-12.

Chicago/Turabian Style

Kim, Arum; Mujumdar, Siddharthya K.; Siegel, Ronald A. 2014. "Swelling Properties of Hydrogels Containing Phenylboronic Acids." Chemosensors 2, no. 1: 1-12.

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