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Healthcare 2015, 3(4), 1097-1120; doi:10.3390/healthcare3041097

Vitamin D and Reproduction: From Gametes to Childhood

1
Department of Nutrition, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
2
Department of Internal Medicine, University of California, Davis One Shields Avenue, Davis, CA 95616, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Sampath Parthasarathy
Received: 16 September 2015 / Revised: 28 October 2015 / Accepted: 3 November 2015 / Published: 9 November 2015
View Full-Text   |   Download PDF [335 KB, uploaded 9 November 2015]   |  

Abstract

Vitamin D is well recognized for its essentiality in maintaining skeletal health. Recent research has suggested that vitamin D may exert a broad range of roles throughout the human life cycle starting from reproduction to adult chronic disease risk. Rates of vitamin D deficiency during pregnancy remain high worldwide. Vitamin D deficiency has been associated with an increased risk of fertility problems, preeclampsia, gestational diabetes, and allergic disease in the offspring. Vitamin D is found naturally in only a few foods thus supplementation can provide an accessible and effective way to raise vitamin D status when dietary intakes and sunlight exposure are low. However, the possibility of overconsumption and possible adverse effects is under debate. The effect of vitamin D supplementation during pregnancy and early life on maternal and infant outcomes will be of particular focus in this review. View Full-Text
Keywords: vitamin D; vitamin D supplementation; pregnancy; fertility; toxicity; preeclampsia; gestational diabetes; allergic disease vitamin D; vitamin D supplementation; pregnancy; fertility; toxicity; preeclampsia; gestational diabetes; allergic disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sowell, K.D.; Keen, C.L.; Uriu-Adams, J.Y. Vitamin D and Reproduction: From Gametes to Childhood. Healthcare 2015, 3, 1097-1120.

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