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Healthcare 2015, 3(2), 296-309; doi:10.3390/healthcare3020296

Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus

School of Nursing, University of Kansas, 3901 Rainbow Blvd., Mailstop 4043, Kansas City, KS 66160, USA
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Academic Editors: Samir Samman and Ian Darnton-Hill
Received: 3 March 2015 / Revised: 20 April 2015 / Accepted: 14 May 2015 / Published: 21 May 2015
(This article belongs to the Special Issue The Close Relationship: Health and Nutrition)
View Full-Text   |   Download PDF [198 KB, uploaded 21 May 2015]   |  

Abstract

Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality with ever increasing prevalence in the United States and worldwide. There is growing body of evidence suggesting that mitochondrial dysfunction secondary to oxidative stress plays a critical role in the pathogenesis of T2DM. Coenzyme Q10 is an important micronutrient acting on the electron transport chain of the mitochondria with two major functions: (1) synthesis of adenosine triphosphate (ATP); and (2) a potent antioxidant. Deficiency in coenzyme Q10 is often seen in patients with T2DM. Whether restoration of coenzyme Q10 will help alleviate oxidative stress, preserve mitochondrial function, and thus improve glycemic control in T2DM is unclear. This article reviews the relationships among oxidative stress, mitochondrial dysfunction, and T2DM and examines the evidence for potential use of coenzyme Q10 as a supplement for the treatment of T2DM. View Full-Text
Keywords: type 2 diabetes mellitus; coenzyme Q10; mitochondrial dysfunction; oxidative stress; antioxidant; adenosine triphosphate type 2 diabetes mellitus; coenzyme Q10; mitochondrial dysfunction; oxidative stress; antioxidant; adenosine triphosphate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shen, Q.; Pierce, J.D. Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus. Healthcare 2015, 3, 296-309.

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