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Healthcare 2014, 2(1), 60-73; doi:10.3390/healthcare2010060

Established and Emerging Biomarkers in Cutaneous Malignant Melanoma

, 1,2
 and 1,*
Received: 27 September 2013 / Revised: 4 December 2013 / Accepted: 7 January 2014 / Published: 14 January 2014
(This article belongs to the Special Issue Melanoma and Neoplasms of Skin)
View Full-Text   |   Download PDF [108 KB, uploaded 14 January 2014]
Abstract: In an era of personalized medicine, disease specific biomarkers play an increasing role in the stratification of high-risk patient groups. Cutaneous malignant melanoma is the most deadly form of skin cancer with an ever-increasing global incidence, especially in patients under 35-years of age. Despite the excellent prognosis for patients diagnosed with early stage disease, metastatic disease still carries significant overall mortality. Biomarkers aim not only to identify high-risk patients, but also to provide potential therapeutic targets for differing patient subgroups. Furthermore, accessibility to tissue samples from a range of disease stages in malignant melanoma, unlike most other solid tissue tumours, provides the unique opportunity to explore the biology of tumour progression that may be relevant in the biology of cancer as a whole. Over the past decade, there have been major advances in targeted therapies, providing new avenues and hope to patients with this devastating disease. This review will focus on most up to date histological, serological and molecular biomarkers in malignant melanoma.
Keywords: cutaneous melanoma; malignancy; biomarkers cutaneous melanoma; malignancy; biomarkers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Verykiou, S.; Ellis, R.A.; Lovat, P.E. Established and Emerging Biomarkers in Cutaneous Malignant Melanoma. Healthcare 2014, 2, 60-73.

AMA Style

Verykiou S, Ellis RA, Lovat PE. Established and Emerging Biomarkers in Cutaneous Malignant Melanoma. Healthcare. 2014; 2(1):60-73.

Chicago/Turabian Style

Verykiou, Stamatina; Ellis, Robert A.; Lovat, Penny E. 2014. "Established and Emerging Biomarkers in Cutaneous Malignant Melanoma." Healthcare 2, no. 1: 60-73.

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