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Proteomes 2014, 2(1), 72-83; doi:10.3390/proteomes2010072
Article

Is Five Percent Too Small? Analysis of the Overlaps between Disorder, Coiled Coil and Collagen Predictions in Complete Proteomes

Received: 31 October 2013; in revised form: 24 January 2014 / Accepted: 27 January 2014 / Published: 7 February 2014
(This article belongs to the Special Issue Feature Paper 2013)
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Abstract: Identification of intrinsic disorder in proteins and proteomes has revealed important novel aspects of protein function and interactions. However, it has been pointed out that several oligomeric fibrillar protein motifs such as coiled coils and collagen triple helical segments can also identified as intrinsically disordered. This feature has not yet been investigated in more detail at the proteome level. The present work aims at the identification and quantification of such overlaps in full proteomes to assess their significance in large-scale studies of protein disorder. It was found that the percentage of cross-predicted residues is around 5% in the human proteome and is generally near that value in other metazoan ones but shows remarkable variation in different organisms. In particular, smaller proteomes are increasingly prone to such cross-predictions, thus, especially the analysis of viral proteomes requires the use of specific prediction tools.
Keywords: intrinsically disordered protein; coiled coil; collagen triple helix; cross-prediction; proteome size intrinsically disordered protein; coiled coil; collagen triple helix; cross-prediction; proteome size
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gáspári, Z. Is Five Percent Too Small? Analysis of the Overlaps between Disorder, Coiled Coil and Collagen Predictions in Complete Proteomes. Proteomes 2014, 2, 72-83.

AMA Style

Gáspári Z. Is Five Percent Too Small? Analysis of the Overlaps between Disorder, Coiled Coil and Collagen Predictions in Complete Proteomes. Proteomes. 2014; 2(1):72-83.

Chicago/Turabian Style

Gáspári, Zoltán. 2014. "Is Five Percent Too Small? Analysis of the Overlaps between Disorder, Coiled Coil and Collagen Predictions in Complete Proteomes." Proteomes 2, no. 1: 72-83.

Proteomes EISSN 2227-7382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert