Plants 2012, 1(2), 74-81; doi:10.3390/plants1020074
Communication

Antibacterial and COX-1 Inhibitory Effect of Medicinal Plants from the Pamir Mountains, Afghanistan

1 Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen, Denmark 2 NaturMedicinsk Museum, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen, Denmark
* Author to whom correspondence should be addressed.
Received: 27 September 2012; in revised form: 15 October 2012 / Accepted: 17 October 2012 / Published: 24 October 2012
(This article belongs to the Special Issue New Journal Plants - Feature Papers)
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Abstract: Plants used to treat inflammatory ailments, pain, fever and infections in the Pamir Mountains in northeastern Afghanistan, were tested for antibacterial and COX-1 inhibitory activity. Water and ethanol extracts of 20 species were tested for antibacterial activity against two gram positive and two gram negative bacteria. The ethanol extract of Arnebia guttata inhibited Staphylococcus aureus with a MIC of 6 µg/mL. Water and ethanol extracts of Ephedra intermedia and the ethanol extracts of Lagochilus cabulicus and Peganum harmala inhibited Staphylococcus aureus at 0.5 mg/mL, and the P. harmala extract further inhibited the growth of Bacillus subtilis and E. coli, also with MICs of 0.5 mg/mL. Ethanol extracts of Artemisia persica (IC50: 0.5 µg/mL), Dragocephalum paulsenii (IC50: 0.5 µg/mL), Ephedra intermedia (IC50: 3.8 µg/mL), Hyoscyamus pusillus, Nepeta parmiriensis (IC50: 0.7 µg/mL) and Rumex patientia subsp. pamiricus (IC50: 3.5 µg/mL) exhibited COX-1 inhibitory activity. The observed in vitro activities support the use of some of the plant species in the traditional medicine systems of the Pamir Mountains.
Keywords: Afghanistan; antibacterial; COX; medicinal plants; Pamir

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MDPI and ACS Style

Jeppesen, A.S.; Soelberg, J.; Jäger, A.K. Antibacterial and COX-1 Inhibitory Effect of Medicinal Plants from the Pamir Mountains, Afghanistan. Plants 2012, 1, 74-81.

AMA Style

Jeppesen AS, Soelberg J, Jäger AK. Antibacterial and COX-1 Inhibitory Effect of Medicinal Plants from the Pamir Mountains, Afghanistan. Plants. 2012; 1(2):74-81.

Chicago/Turabian Style

Jeppesen, Anne S.; Soelberg, Jens; Jäger, Anna K. 2012. "Antibacterial and COX-1 Inhibitory Effect of Medicinal Plants from the Pamir Mountains, Afghanistan." Plants 1, no. 2: 74-81.

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