Modeling the Kinetic Behavior of Reactive Oxygen Species with Cerium Dioxide Nanoparticles
Abstract
:1. Introduction
2. Mathematical Models
3. Results
3.1. Steady-State Kinetics
3.2. Time-Dependent Kinetics
3.3. Non-Dimensionalization
4. Results
Time-Dependent Kinetics
5. Discussion
6. Conclusions
- When some is oxidized or reduced, this treatment has little effect on sparing. That is because both and consume
- Hydrogen peroxide is consumed, consistent with observations that ceria is working on an ALS murine model.
- If the antagonist (hydrogen peroxide) goes away (i.e., the organism is healthy), the entire reaction sequence shuts down (i.e., ceria is not immunosuppressant, nor does it interfere with mitochondrial function).
- The system is catalytic (regenerative and not sacrificial).
- The system is both self-limiting and self-balancing.
- It appears to directly control reactive oxygen species and specifically superoxide, perhaps due to the nature of the oxygen vacancies within the crystal.
- Within the framework of the reaction sequence as described, the dominant ions are the cerium 4+ state and H+ initially but in totality, the chemical reaction system requires both 4+ and 3+ cerium ions, which are constantly in balance and equilibrating.
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Reed, K.; Bush, N.; Burns, Z.; Doherty, G.; Foley, T.; Milone, M.; L. Maki, K.; Cromer, M. Modeling the Kinetic Behavior of Reactive Oxygen Species with Cerium Dioxide Nanoparticles. Biomolecules 2019, 9, 447. https://doi.org/10.3390/biom9090447
Reed K, Bush N, Burns Z, Doherty G, Foley T, Milone M, L. Maki K, Cromer M. Modeling the Kinetic Behavior of Reactive Oxygen Species with Cerium Dioxide Nanoparticles. Biomolecules. 2019; 9(9):447. https://doi.org/10.3390/biom9090447
Chicago/Turabian StyleReed, Kenneth, Nathan Bush, Zachary Burns, Gwendolyn Doherty, Thomas Foley, Matthew Milone, Kara L. Maki, and Michael Cromer. 2019. "Modeling the Kinetic Behavior of Reactive Oxygen Species with Cerium Dioxide Nanoparticles" Biomolecules 9, no. 9: 447. https://doi.org/10.3390/biom9090447