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Biomolecules 2018, 8(3), 91; https://doi.org/10.3390/biom8030091

Stimulation of the Production of Prostaglandin E2 by Ethyl Gallate, a Natural Phenolic Compound Richly Contained in Longan

1
Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China
2
School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China
*
Author to whom correspondence should be addressed.
Received: 9 May 2018 / Revised: 1 July 2018 / Accepted: 3 July 2018 / Published: 6 September 2018
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Abstract

Ethyl gallate is a phenolic compound richly contained in Longan. In traditional Chinese medicine, Longan is widely known as a fruit with “hot” properties, with a tendency to promote inflammatory and certain other responses. The mechanism for its proinflammatory as well as health beneficial effects is poorly understood. Based on our earlier observation that certain natural phenolic compounds can serve as reducing cosubstrates for cyclooxygenases (COXs), we sought to test a hypothesis that ethyl gallate may activate the catalytic activity of the COX enzymes. Results from studies using cultured cells and animals show that ethyl gallate can activate the production of prostaglandin E2, a representative prostaglandin tested in this study. Computational analysis indicates that ethyl gallate can activate the peroxidase active sites of COX-1 and COX-2 by serving as a reducing cosubstrate. The effect of ethyl gallate is abrogated by galangin, which is known to bind to the same peroxidase active sites of COX-1 and COX-2 as a competitive inhibitor. The findings of this study offer support for a novel hypothesis that the proinflammatory as well as health beneficial effects of Longan may be partly attributable to the activation of COX-1 and COX-2 by ethyl gallate. View Full-Text
Keywords: ethyl gallate; cyclooxygenase; peroxidase activity; mechanism of catalytic activation ethyl gallate; cyclooxygenase; peroxidase activity; mechanism of catalytic activation
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Wang, H.R.; Sui, H.C.; Ding, Y.Y.; Zhu, B.T. Stimulation of the Production of Prostaglandin E2 by Ethyl Gallate, a Natural Phenolic Compound Richly Contained in Longan. Biomolecules 2018, 8, 91.

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