A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets
Abstract
:1. Introduction
1.1. Structure of SIRT6 and its Activity
1.2. Observed Implications of SIRT6
2. Role of SIRT6 in DNA Repair and Aging-Related Processes
2.1. Maintenance of Telomeres
2.2. Base Excision Repair
2.3. Double Strand DNA Break Repair
2.4. Aging and Life Expectancy
3. SIRT6 in Glucose Metabolism and Diabetes
3.1. SIRT6 in Glycolysis and the Suppression of Glucose-Metabolic Genes
3.2. SIRT6 in Gluconeogenesis
4. Pharmacological Intervention with Small Molecule SIRT6 Inhibitors for SIRT Associated Ailments
5. SIRT6 in Heart Disease
6. SIRT6 and Cancer
6.1. Tumor Growth Resulting from Altered Glycolysis
6.2. SIRT6 and the Initiation of Hepatic Cancer
6.3. Aberrant Behavior of SIRT6 in Other Forms of Cancer
7. SIRT6 in Neurodegenerative Diseases and Brain Aging
8. Advances Made with SIRT6 in Other Areas
9. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Substrate | Linked Functions in Cell |
---|---|
H3K9ac | Regulation of transcription, stability of telomeres, response to DNA damage |
H3K56ac | Regulation of transcription, stability of telomeres, response to DNA damage |
H3K18ac | Silencing of heterochromatin |
NPM1 | Cellular Senescence |
PARP1 | DNA double-strand break repair and base-excision repair |
KAP1 | DNA double-strand break repair |
Asinex ID | Compound Structure | Percentage Inhibition of SIRT6 at 200 µM Concentration of the Compound |
---|---|---|
SYN17739303 | 100 ± 4 | |
BAS13555470 | 62 ± 7 | |
SYN10366754 | 12 ± 3 | |
BAS00417531 | 66 ± 6 |
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Khan, R.I.; Nirzhor, S.S.R.; Akter, R. A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets. Biomolecules 2018, 8, 44. https://doi.org/10.3390/biom8030044
Khan RI, Nirzhor SSR, Akter R. A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets. Biomolecules. 2018; 8(3):44. https://doi.org/10.3390/biom8030044
Chicago/Turabian StyleKhan, Rubayat Islam, Saif Shahriar Rahman Nirzhor, and Raushanara Akter. 2018. "A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets" Biomolecules 8, no. 3: 44. https://doi.org/10.3390/biom8030044