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Biomolecules 2017, 7(3), 60; doi:10.3390/biom7030060

The Role of Functional Amyloids in Multicellular Growth and Development of Gram-Positive Bacteria

1
Terrestrial Biofilms Group, Institute of Microbiology, Friedrich Schiller University Jena, 07743 Jena, Germany
2
Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Lyngby, Denmark
3
Institute of Biology, Leiden University, 2333BE Leiden, The Netherlands
*
Authors to whom correspondence should be addressed.
Academic Editors: Margaret Sunde, Matthew Chapman and Daniel Otzen
Received: 7 July 2017 / Revised: 1 August 2017 / Accepted: 3 August 2017 / Published: 7 August 2017
(This article belongs to the Special Issue Functional Amyloids)
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Abstract

Amyloid fibrils play pivotal roles in all domains of life. In bacteria, these fibrillar structures are often part of an extracellular matrix that surrounds the producing organism and thereby provides protection to harsh environmental conditions. Here, we discuss the role of amyloid fibrils in the two distant Gram-positive bacteria, Streptomyces coelicolor and Bacillus subtilis. We describe how amyloid fibrils contribute to a multitude of developmental processes in each of these systems, including multicellular growth and community development. Despite this variety of tasks, we know surprisingly little about how their assembly is organized to fulfill all these roles. View Full-Text
Keywords: amyloid fiber; Streptomyces; Bacillus subtilis; chaplin; TasA; biofilm; extracellular matrix; development; multicellular growth amyloid fiber; Streptomyces; Bacillus subtilis; chaplin; TasA; biofilm; extracellular matrix; development; multicellular growth
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dragoš, A.; Kovács, Á.T.; Claessen, D. The Role of Functional Amyloids in Multicellular Growth and Development of Gram-Positive Bacteria. Biomolecules 2017, 7, 60.

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