NMR Meets Tau: Insights into Its Function and Pathology
AbstractIn this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate phosphorylation patterns by different kinases, and its non-destructive character has allowed functional assays with the same samples. Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function. View Full-Text
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Lippens, G.; Landrieu, I.; Smet, C.; Huvent, I.; Gandhi, N.S.; Gigant, B.; Despres, C.; Qi, H.; Lopez, J. NMR Meets Tau: Insights into Its Function and Pathology. Biomolecules 2016, 6, 28.
Lippens G, Landrieu I, Smet C, Huvent I, Gandhi NS, Gigant B, Despres C, Qi H, Lopez J. NMR Meets Tau: Insights into Its Function and Pathology. Biomolecules. 2016; 6(2):28.Chicago/Turabian Style
Lippens, Guy; Landrieu, Isabelle; Smet, Caroline; Huvent, Isabelle; Gandhi, Neha S.; Gigant, Benoît; Despres, Clément; Qi, Haoling; Lopez, Juan. 2016. "NMR Meets Tau: Insights into Its Function and Pathology." Biomolecules 6, no. 2: 28.
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