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Biomolecules 2016, 6(2), 21; doi:10.3390/biom6020021

New Features about Tau Function and Dysfunction

1
CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas), Valderrebollo 5, 28031 Madrid, Spain
2
CIEN Foundation, Valderrebollo 5, 28041 Madrid, Spain
3
Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Nicolás cabrera 1, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Claude M. Wischik and Charles R. Harrington
Received: 29 October 2015 / Revised: 9 March 2016 / Accepted: 13 April 2016 / Published: 19 April 2016
(This article belongs to the Special Issue Tau Protein and Alzheimer’s disease)
View Full-Text   |   Download PDF [221 KB, uploaded 19 April 2016]

Abstract

Tau is a brain microtubule-associated protein that directly binds to a microtubule and dynamically regulates its structure and function. Under pathological conditions, tau self-assembles into filamentous structures that end up forming neurofibrillary tangles. Prominent tau neurofibrillary pathology is a common feature in a number of neurodegenerative disorders, collectively referred to as tauopathies, the most common of which is Alzheimer’s disease (AD). Beyond its classical role as a microtubule-associated protein, recent advances in our understanding of tau cellular functions have revealed novel insights into their important role during pathogenesis and provided potential novel therapeutic targets. Regulation of tau behavior and function under physiological and pathological conditions is mainly achieved through post-translational modifications, including phosphorylation, glycosylation, acetylation, and truncation, among others, indicating the complexity and variability of factors influencing regulation of tau toxicity, all of which have significant implications for the development of novel therapeutic approaches in various neurodegenerative disorders. A more comprehensive understanding of the molecular mechanisms regulating tau function and dysfunction will provide us with a better outline of tau cellular networking and, hopefully, offer new clues for designing more efficient approaches to tackle tauopathies in the near future. View Full-Text
Keywords: Alzheimer’s disease; immunotherapy; neurodegeneration; spreading; tau; tauopathies Alzheimer’s disease; immunotherapy; neurodegeneration; spreading; tau; tauopathies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Medina, M.; Hernández, F.; Avila, J. New Features about Tau Function and Dysfunction. Biomolecules 2016, 6, 21.

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