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Biomolecules 2016, 6(1), 1; doi:10.3390/biom6010001

Alcoholic Liver Disease: Update on the Role of Dietary Fat

1
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
2
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
3
Robley Rex Veterans Medical Center, Louisville, KY 40202, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Natalia Osna and Kusum Kharbanda
Received: 31 August 2015 / Revised: 23 November 2015 / Accepted: 7 December 2015 / Published: 6 January 2016
(This article belongs to the Collection Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment)
View Full-Text   |   Download PDF [815 KB, uploaded 6 January 2016]   |  

Abstract

Alcoholic liver disease (ALD) spans a spectrum of liver pathology, including fatty liver, alcoholic steatohepatitis, and cirrhosis. Accumulating evidence suggests that dietary factors, including dietary fat, as well as alcohol, play critical roles in the pathogenesis of ALD. The protective effects of dietary saturated fat (SF) and deleterious effects of dietary unsaturated fat (USF) on alcohol-induced liver pathology are well recognized and documented in experimental animal models of ALD. Moreover, it has been demonstrated in an epidemiological study of alcoholic cirrhosis that dietary intake of SF was associated with a lower mortality rates, whereas dietary intake of USF was associated with a higher mortality. In addition, oxidized lipids (dietary and in vivo generated) may play a role in liver pathology. The understanding of how dietary fat contributes to the ALD pathogenesis will enhance our knowledge regarding the molecular mechanisms of ALD development and progression, and may result in the development of novel diet-based therapeutic strategies for ALD management. This review explores the relevant scientific literature and provides a current understanding of recent advances regarding the role of dietary lipids in ALD pathogenesis. View Full-Text
Keywords: alcoholic liver disease; saturated and unsaturated dietary fat; oxidized dietary lipids; oxidized linoleic acid metabolites; gut microbiota alcoholic liver disease; saturated and unsaturated dietary fat; oxidized dietary lipids; oxidized linoleic acid metabolites; gut microbiota
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kirpich, I.A.; Miller, M.E.; Cave, M.C.; Joshi-Barve, S.; McClain, C.J. Alcoholic Liver Disease: Update on the Role of Dietary Fat. Biomolecules 2016, 6, 1.

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