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Biomolecules 2015, 5(4), 3309-3338; doi:10.3390/biom5043309

Role of microRNAs in Alcohol-Induced Multi-Organ Injury

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198, USA
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Author to whom correspondence should be addressed.
Academic Editors: Natalia Osna and Kusum Kharbanda
Received: 29 August 2015 / Accepted: 16 November 2015 / Published: 20 November 2015
(This article belongs to the Collection Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment)
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Abstract

Alcohol consumption and its abuse is a major health problem resulting in significant healthcare cost in the United States. Chronic alcoholism results in damage to most of the vital organs in the human body. Among the alcohol-induced injuries, alcoholic liver disease is one of the most prevalent in the United States. Remarkably, ethanol alters expression of a wide variety of microRNAs that can regulate alcohol-induced complications or dysfunctions. In this review, we will discuss the role of microRNAs in alcoholic pancreatitis, alcohol-induced liver damage, intestinal epithelial barrier dysfunction, and brain damage including altered hippocampus structure and function, and neuronal loss, alcoholic cardiomyopathy, and muscle damage. Further, we have reviewed the role of altered microRNAs in the circulation, teratogenic effects of alcohol, and during maternal or paternal alcohol consumption. View Full-Text
Keywords: alcoholism; miRNA; lncRNA; teratogen; alcoholic liver disease; alcoholic pancreatitis alcoholism; miRNA; lncRNA; teratogen; alcoholic liver disease; alcoholic pancreatitis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Natarajan, S.K.; Pachunka, J.M.; Mott, J.L. Role of microRNAs in Alcohol-Induced Multi-Organ Injury. Biomolecules 2015, 5, 3309-3338.

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