Next Article in Journal
Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2
Next Article in Special Issue
Update on Alcoholic Hepatitis
Previous Article in Journal
HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA
Previous Article in Special Issue
Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity
Article Menu

Export Article

Open AccessReview
Biomolecules 2015, 5(4), 2840-2853; doi:10.3390/biom5042840

Chronic Ethanol Exposure: Pathogenesis of Pulmonary Disease and Dysfunction

1
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida Health, Tampa, FL 33612, USA
2
Department of Internal Medicine, Division of Allergy and Immunology, University of South Florida Health, Tampa, FL 33612, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Natalia Osna and Kusum Kharbanda
Received: 30 July 2015 / Revised: 4 September 2015 / Accepted: 28 September 2015 / Published: 20 October 2015
(This article belongs to the Collection Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment)
View Full-Text   |   Download PDF [95 KB, uploaded 20 October 2015]   |  

Abstract

Ethanol (EtOH) is the world’s most commonly used drug, and has been widely recognized as a risk factor for developing lung disorders. Chronic EtOH exposure affects all of the organ systems in the body and increases the risk of developing pulmonary diseases such as acute lung injury and pneumonia, while exacerbating the symptoms and resulting in increased mortality in many other lung disorders. EtOH and its metabolites inhibit the immune response of alveolar macrophages (AMs), increase airway leakage, produce damaging reactive oxygen species (ROS), and disrupt the balance of antioxidants/oxidants within the lungs. In this article, we review the role of EtOH exposure in the pathogenesis and progression of pulmonary disease. View Full-Text
Keywords: lung; ethanol; dysfunction; COPD; pneumonia lung; ethanol; dysfunction; COPD; pneumonia
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Traphagen, N.; Tian, Z.; Allen-Gipson, D. Chronic Ethanol Exposure: Pathogenesis of Pulmonary Disease and Dysfunction. Biomolecules 2015, 5, 2840-2853.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top