4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product†
AbstractThis review on recent research advances of the lipid peroxidation product 4-hydroxy-nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues, II. the diverse biochemical reactions with Michael adduct formation as the most prominent one, III. the endogenous targets of HNE, primarily peptides and proteins (here the mechanisms of covalent adduct formation are described and the (patho-) physiological consequences discussed), and IV. the metabolism of HNE leading to a great number of degradation products, some of which are excreted in urine and may serve as non-invasive biomarkers of oxidative stress. View Full-Text
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Schaur, R.J.; Siems, W.; Bresgen, N.; Eckl, P.M. 4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product. Biomolecules 2015, 5, 2247-2337.
Schaur RJ, Siems W, Bresgen N, Eckl PM. 4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product. Biomolecules. 2015; 5(4):2247-2337.Chicago/Turabian Style
Schaur, Rudolf J.; Siems, Werner; Bresgen, Nikolaus; Eckl, Peter M. 2015. "4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product." Biomolecules 5, no. 4: 2247-2337.