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Biomolecules 2015, 5(3), 1979-1989; doi:10.3390/biom5031979

Optimized Production of Xylitol from Xylose Using a Hyper-Acidophilic Candida tropicalis

Department of Life Sciences and Biotechnology, University of Ferrara, Via L. Borsari 46, Ferrara 44121, Italy
Author to whom correspondence should be addressed.
Academic Editor: Jürg Bähler
Received: 6 May 2015 / Revised: 31 July 2015 / Accepted: 3 August 2015 / Published: 19 August 2015
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The yeast Candida tropicalis DSM 7524 produces xylitol, a natural, low-calorie sweetener, by fermentation of xylose. In order to increase xylitol production rate during the submerged fermentation process, some parameters-substrate (xylose) concentration, pH, aeration rate, temperature and fermentation strategy-have been optimized. The maximum xylitol yield reached at 60–80 g/L initial xylose concentration, pH 5.5 at 37 °C was 83.66% (w/w) on consumed xylose in microaerophilic conditions (kLa = 2·h−1). Scaling up on 3 L fermenter, with a fed-batch strategy, the best xylitol yield was 86.84% (w/w), against a 90% of theoretical yield. The hyper-acidophilic behaviour of C. tropicalis makes this strain particularly promising for industrial application, due to the possibility to work in non-sterile conditions. View Full-Text
Keywords: xylitol; xylose; fed batch fermentation; Candida tropicalis; hyper-acidophylic xylitol; xylose; fed batch fermentation; Candida tropicalis; hyper-acidophylic

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tamburini, E.; Costa, S.; Marchetti, M.G.; Pedrini, P. Optimized Production of Xylitol from Xylose Using a Hyper-Acidophilic Candida tropicalis. Biomolecules 2015, 5, 1979-1989.

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