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Biomolecules 2015, 5(3), 1580-1599; doi:10.3390/biom5031580

Functional Integration of mRNA Translational Control Programs

1
Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
2
Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
3
Interdisciplinary BioSciences Graduate Program, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
4
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
5
Institute of Biomembranes and Bioenergetics, National Research Council, Bari 70126, Italy
6
Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, Bari 70125, Italy
7
Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Current address: Centre for Genomic Regulation, Department of Differentiation and Cancer, C/Dr. Aiguader 88, Barcelona 08003, Spain.
*
Author to whom correspondence should be addressed.
Academic Editor: André P. Gerber
Received: 22 April 2015 / Revised: 20 June 2015 / Accepted: 14 July 2015 / Published: 21 July 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
View Full-Text   |   Download PDF [879 KB, uploaded 21 July 2015]   |  

Abstract

Regulated mRNA translation plays a key role in control of cell cycle progression in a variety of physiological and pathological processes, including in the self-renewal and survival of stem cells and cancer stem cells. While targeting mRNA translation presents an attractive strategy for control of aberrant cell cycle progression, mRNA translation is an underdeveloped therapeutic target. Regulated mRNAs are typically controlled through interaction with multiple RNA binding proteins (RBPs) but the mechanisms by which the functions of distinct RBPs bound to a common target mRNA are coordinated are poorly understood. The challenge now is to gain insight into these mechanisms of coordination and to identify the molecular mediators that integrate multiple, often conflicting, inputs. A first step includes the identification of altered mRNA ribonucleoprotein complex components that assemble on mRNAs bound by multiple, distinct RBPs compared to those recruited by individual RBPs. This review builds upon our knowledge of combinatorial control of mRNA translation during the maturation of oocytes from Xenopus laevis, to address molecular strategies that may mediate RBP diplomacy and conflict resolution for coordinated control of mRNA translational output. Continued study of regulated ribonucleoprotein complex dynamics promises valuable new insights into mRNA translational control and may suggest novel therapeutic strategies for the treatment of disease. View Full-Text
Keywords: Musashi; CPEB; RNA-binding protein; mRNA translation; combinatorial control; mRNP; regulation Musashi; CPEB; RNA-binding protein; mRNA translation; combinatorial control; mRNP; regulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

MacNicol, M.C.; Cragle, C.E.; Arumugam, K.; Fosso, B.; Pesole, G.; MacNicol, A.M. Functional Integration of mRNA Translational Control Programs. Biomolecules 2015, 5, 1580-1599.

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