Anti-Amyloidogenic Properties of Some Phenolic Compounds
Abstract
:1. Introduction
2. Results and Discussion
2.1. Inhibitory Effects of Phenolic Compounds on Aβ42 Aggregation
2.2. Protection Effect of Selected Inhibitors against the Cytotoxicity of Aβ42
2.3. Selected Compounds Do not Inhibit Aβ42 Oligomer Formation (TEM)
2.4. PAGE and Western-Blot of Aβ42 Co-Incubated with Selected Potent Compounds
3. Experimental Section
3.1. Yeast Strains
3.2. Compound Library of Polyphenol Derivatives (21 Compounds)
3.3. Flow Cytometry Analysis of Compound-Treated Transformants
3.4. Synthetic Aβ42 Peptide Preparation and Analysis
3.5. Thioflavin T (ThT) Fluorescence Assay
3.6. Sample Preparation of Compounds Co-Incubated with Aβ42 Peptide for Gel Electrophoresis
3.7. SDS PAGE and Silver Staining for Detection of Aβ42 Oligomers in the Presence of Compounds
3.8. Western-Blot for Detection of Potential Aβ42 Fibril Inhibitors
3.9. Transmission Electron Microscope (TEM) Imaging
Sample Preparation for TEM
3.10. Statistical Analysis
4. Conclusions
Acknowledgments
Author Contributions
Conflict of Interest
References
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Porzoor, A.; Alford, B.; Hügel, H.M.; Grando, D.; Caine, J.; Macreadie, I. Anti-Amyloidogenic Properties of Some Phenolic Compounds. Biomolecules 2015, 5, 505-527. https://doi.org/10.3390/biom5020505
Porzoor A, Alford B, Hügel HM, Grando D, Caine J, Macreadie I. Anti-Amyloidogenic Properties of Some Phenolic Compounds. Biomolecules. 2015; 5(2):505-527. https://doi.org/10.3390/biom5020505
Chicago/Turabian StylePorzoor, Afsaneh, Benjamin Alford, Helmut M. Hügel, Danilla Grando, Joanne Caine, and Ian Macreadie. 2015. "Anti-Amyloidogenic Properties of Some Phenolic Compounds" Biomolecules 5, no. 2: 505-527. https://doi.org/10.3390/biom5020505