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Biomolecules 2013, 3(1), 143-156; doi:10.3390/biom3010143
Review

Why YRNAs? About Versatile RNAs and Their Functions

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Received: 31 December 2012; in revised form: 27 January 2013 / Accepted: 31 January 2013 / Published: 8 February 2013
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Abstract: Y RNAs constitute a family of highly conserved small noncoding RNAs (in humans: 83-112 nt; Y1, Y3, Y4 and Y5). They are transcribed from individual genes by RNA-polymerase III and fold into conserved stem-loop-structures. Although discovered 30 years ago, insights into the cellular and physiological role of Y RNAs remains incomplete. In this review, we will discuss knowledge on the structural properties, associated proteins and discuss proposed functions of Y RNAs. We suggest Y RNAs to be an integral part of ribonucleoprotein networks within cells and could therefore have substantial influence on many different cellular processes. Putative functions of Y RNAs include small RNA quality control, DNA replication, regulation of the cellular stress response and proliferation. This suggests Y RNAs as essential regulators of cell fate and indicates future avenues of research, which will provide novel insights into the role of small noncoding RNAs in gene expression.
Keywords: Y RNA; Ro60; La; ncRNA Y RNA; Ro60; La; ncRNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Köhn, M.; Pazaitis, N.; Hüttelmaier, S. Why YRNAs? About Versatile RNAs and Their Functions. Biomolecules 2013, 3, 143-156.

AMA Style

Köhn M, Pazaitis N, Hüttelmaier S. Why YRNAs? About Versatile RNAs and Their Functions. Biomolecules. 2013; 3(1):143-156.

Chicago/Turabian Style

Köhn, Marcel; Pazaitis, Nikolaos; Hüttelmaier, Stefan. 2013. "Why YRNAs? About Versatile RNAs and Their Functions." Biomolecules 3, no. 1: 143-156.



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