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Biomolecules 2013, 3(1), 157-167; doi:10.3390/biom3010157

MicroRNA Expression in Cystic Fibrosis Airway Epithelium

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
Received: 14 January 2013 / Revised: 1 February 2013 / Accepted: 3 February 2013 / Published: 11 February 2013
(This article belongs to the Special Issue Non-coding RNA)
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MicroRNAs (miRs) have emerged as major regulators of the protein content of a cell. In the most part, miRs negatively regulate target mRNA expression, with sets of miRs predicted to regulate certain signaling pathways. The miR expression profile of endobronchial brushings is altered in people with cystic fibrosis (CF) compared to those without CF. How this impacts on CF has important implications for our growing understanding of the pathophysiology of CF lung disease and the development of new therapeutics to treat its pulmonary manifestations. Herein we discuss the potential consequences of altered miR expression in CF airway epithelium particularly with respect to cystic fibrosis transmembrane conductance regulator (CFTR) expression, innate immunity and toll-like receptor signalling and explore how best to exploit these changes for therapeutic benefit.
Keywords: cystic fibrosis; airway epithelium; microRNA cystic fibrosis; airway epithelium; microRNA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Greene, C.M. MicroRNA Expression in Cystic Fibrosis Airway Epithelium. Biomolecules 2013, 3, 157-167.

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